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Tbio
GID8
Glucose-induced degradation protein 8 homolog

Protein Classes
Protein Summary
Description
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266069
  • ENSP00000266069
  • ENSG00000101193

Symbol
  • C20orf11
  • TWA1
  • TWA1
  • C20orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor binding site profile
0.89
transcription factor perturbation
0.84
microRNA
0.72
PubMedID
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (70)
1 – 10 of 70
BMP1
Tchem
Novelty: 0.00299518
p_int: 0.989999363
p_ni: 0.010000637
Data Source: BioPlex
TDGF1
Tbio
Novelty: 0.00527099
p_int: 0.987881985
p_ni: 0.012118015
Score: 0.547
Data Source: BioPlex,STRINGDB
PRG3
Tbio
Novelty: 0.09431986
p_int: 0.984003378
p_ni: 0.015996621
p_wrong: 1e-9
Data Source: BioPlex
SPON1
Tbio
Novelty: 0.01071398
p_int: 0.981752038
p_ni: 0.018247962
Data Source: BioPlex
PIGT
Tbio
Family: Enzyme
Novelty: 0.02539879
p_int: 0.965733172
p_ni: 0.034266827
p_wrong: 1e-9
Data Source: BioPlex
GCG
Tchem
Novelty: 0.00004879
p_int: 0.953960302
p_ni: 0.046039698
Data Source: BioPlex
CST8
Tbio
Novelty: 0.02316886
p_int: 0.951524294
p_ni: 0.048475706
Data Source: BioPlex
RMND5A
Tbio
Novelty: 0.01820349
p_int: 0.936320732
p_ni: 0.063679266
p_wrong: 1e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.933126872
p_ni: 0.066873128
Data Source: BioPlex
NMB
Tbio
Novelty: 0.00729571
p_int: 0.929395808
p_ni: 0.070604192
Data Source: BioPlex
Publication Statistics
PubMed Score  6.22

PubMed score by year
PubTator Score  5.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer