Tbio GID8 Glucose-induced degradation protein 8 homolog

Protein Summary

Description

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046).

Uniprot Accession IDs

• Q9NWU2
• E1P5I3
• Q8N5M5

Gene Name

• GID8

Ensembl ID

• ENST00000266069
• ENSP00000266069
• ENSG00000101193

Symbol

• C20orf11
• TWA1
• TWA1
• C20orf11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
transcription factor binding site profile	0.89
transcription factor perturbation	0.84
microRNA	0.72
PubMedID	0.63

Protein Classes

PANTHER Classes

Protein / Transporter / Glucose-induced Degradation Protein 8 Homolog

Protein / Transfer/carrier Protein / Glucose-induced Degradation Protein 8 Homolog

DTO Classes

Protein / Transporter / Glucose-induced Degradation Protein 8 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.11   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.11   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0