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Tchem
AURKAIP1
Aurora kinase A-interacting protein

Protein Summary
Description
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321751
  • ENSP00000319778
  • ENSG00000175756
  • ENST00000338338
  • ENSP00000340656
  • ENST00000338370
  • ENSP00000342676
  • ENST00000378853
  • ENSP00000368130

Symbol
  • AIP
  • AKIP
  • MRPS38
  • AIP
  • AKIP
  • MRP-S38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.88
transcription factor binding site profile
0.77
histone modification site profile
0.76
transcription factor
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.91   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.91   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL572878
chemical structure image
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aurora kinase A interacting protein 1
VGNC:451
100611076
Mouse
MGI:1913327
66077
Dog
aurora kinase A interacting protein 1
607067
Cow
aurora kinase A interacting protein 1
VGNC:26350
506359
Opossum
aurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aurora kinase A interacting protein 1
Mouse
Dog
aurora kinase A interacting protein 1
Cow
aurora kinase A interacting protein 1
Opossum
aurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NWT8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Protein-Protein Interactions (157)
1 – 10 of 157
MMADHC
Tbio
Novelty: 0.02299238
p_int: 0.999989564
p_ni: 0.000010436
Data Source: BioPlex
NRDC
Tbio
Family: Enzyme
Novelty: 0.01825187
p_int: 0.999955658
p_ni: 0.000044342
Data Source: BioPlex
NOA1
Tbio
Novelty: 0.01478325
p_int: 0.999059175
p_ni: 0.000940824
p_wrong: 1e-9
Score: 0.77
Data Source: BioPlex,STRINGDB
WDR83
Tbio
Novelty: 0.11602568
p_int: 0.998764741
p_ni: 0.001234797
p_wrong: 4.62e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
STRBP
Tbio
Novelty: 0.00919158
p_int: 0.99762392
p_ni: 0.00237608
Score: 0.248
Data Source: BioPlex,STRINGDB
NSUN4
Tbio
Family: Enzyme
Novelty: 0.15593771
p_int: 0.997042713
p_ni: 0.002886208
p_wrong: 0.000071078
Score: 0.499
Data Source: BioPlex,STRINGDB
MRPS18C
Tdark
Novelty: 0.42868428
p_int: 0.993110106
p_ni: 0.006889883
p_wrong: 1.1e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
DCAF1
Tbio
Novelty: 0.0170232
p_int: 0.99212492
p_ni: 0.00787508
Data Source: BioPlex
UBE2O
Tbio
Novelty: 0.07084123
p_int: 0.989284756
p_ni: 0.010715243
p_wrong: 1e-9
Data Source: BioPlex
MRPS11
Tdark
Novelty: 0.29449255
p_int: 0.987329342
p_ni: 0.012670658
Score: 0.997
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.91

PubMed score by year
PubTator Score  1.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer