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Tbio
PAK1IP1
p21-activated protein kinase-interacting protein 1

Protein Summary
Description
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379568
  • ENSP00000368887
  • ENSG00000111845
  • ENST00000644756
  • ENSP00000496482
  • ENSG00000285226

Symbol
  • PIP1
  • WDR84
  • PIP1
  • MAK11
  • WDR84
  • hPIP1
  • bA421M1.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.9
transcription factor binding site profile
0.88
disease perturbation
0.87
PubMedID
0.76


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.42   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.42   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PAK1 interacting protein 1
VGNC:11140
463143
Macaque
PAK1 interacting protein 1
697856
Mouse
MGI:1915333
68083
Rat
RGD:1565353
361232
Dog
PAK1 interacting protein 1
VGNC:44244
478719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PAK1 interacting protein 1
Macaque
PAK1 interacting protein 1
Mouse
Rat
Dog
PAK1 interacting protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NWT1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (262)
1 – 10 of 262
PPAN
Tbio
Novelty: 0.01063709
p_int: 0.998657169
p_ni: 0.001342831
Score: 0.847
Data Source: BioPlex,STRINGDB
RPL30
Tbio
Novelty: 0.0134194
p_int: 0.975070697
p_ni: 0.024929302
Score: 0.338
Data Source: BioPlex,STRINGDB
CNBP
Tbio
Novelty: 0.00404247
p_int: 0.957586017
p_ni: 0.042413983
Score: 0.323
Data Source: BioPlex,STRINGDB
RBM4
Tbio
Novelty: 0.02034191
p_int: 0.95344881
p_ni: 0.04655119
Score: 0.153
Data Source: BioPlex,STRINGDB
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.944019514
p_ni: 0.055980473
p_wrong: 1.3e-8
Score: 0.332
Data Source: BioPlex,STRINGDB
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.91021514
p_ni: 0.08978486
Score: 0.874
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.883253757
p_ni: 0.116746243
Score: 0.811
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.848998921
p_ni: 0.151001076
p_wrong: 3e-9
Data Source: BioPlex
PRR11
Tbio
Novelty: 0.05077483
p_int: 0.826344546
p_ni: 0.173655453
p_wrong: 1e-9
Data Source: BioPlex
ZNF2
Tbio
Family: TF
Novelty: 0.01062543
p_int: 0.812914262
p_ni: 0.187085738
Data Source: BioPlex
Publication Statistics
PubMed Score  11.42

PubMed score by year
PubTator Score  5.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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