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Tbio
RMND1
Required for meiotic nuclear division protein 1 homolog

Protein Summary
Description
Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome (PubMed:23022098, PubMed:25604853). The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in mitochondrial translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-11. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367303
  • ENSP00000356272
  • ENSG00000155906
  • ENST00000444024
  • ENSP00000412708
  • ENST00000491268
  • ENSP00000494948

Symbol
  • C6orf96
  • RMD1
  • C6orf96
  • COXPD11
  • bA351K16
  • bA351K16.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.86
interacting protein
0.85
disease perturbation
0.83
gene perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.08   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.08   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
76.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
76.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
required for meiotic nuclear division 1 homolog
VGNC:3682
463077
Macaque
required for meiotic nuclear division 1 homolog
704665
Mouse
MGI:1913334
66084
Rat
RGD:1309546
292268
Dog
required for meiotic nuclear division 1 homolog
VGNC:53761
476247
Species
Name
OMA
EggNOG
Inparanoid
Chimp
required for meiotic nuclear division 1 homolog
Macaque
required for meiotic nuclear division 1 homolog
Mouse
Rat
Dog
required for meiotic nuclear division 1 homolog
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (72)
1 – 10 of 72
SMIM21
Tdark
Novelty: 1.27326849
p_int: 0.999651885
p_ni: 0.000348115
Data Source: BioPlex
DEFB104A
Tbio
Novelty: 0.0468791
p_int: 0.999343455
p_ni: 0.000656545
Data Source: BioPlex
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.995112469
p_ni: 0.004887531
p_wrong: 1e-9
Data Source: BioPlex
CHST12
Tbio
Family: Enzyme
Novelty: 0.04560641
p_int: 0.989388604
p_ni: 0.010611395
Data Source: BioPlex
TPTE2
Tbio
Family: Enzyme
Novelty: 0.04710658
p_int: 0.989279214
p_ni: 0.010720781
p_wrong: 5e-9
Data Source: BioPlex
LEAP2
Tbio
Novelty: 0.01484908
p_int: 0.9880238
p_ni: 0.0119762
Data Source: BioPlex
DNAJC1
Tbio
Family: TF
Novelty: 0.07277849
p_int: 0.985255747
p_ni: 0.014740309
p_wrong: 0.000003944
Score: 0.16
Data Source: BioPlex,STRINGDB
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.982412188
p_ni: 0.017587812
Data Source: BioPlex
RETREG3
Tdark
Novelty: 0.99215801
p_int: 0.980515905
p_ni: 0.01945554
p_wrong: 0.000028555
Score: 0.195
Data Source: BioPlex,STRINGDB
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.978744081
p_ni: 0.021255919
Data Source: BioPlex
Publication Statistics
PubMed Score  18.08

PubMed score by year
PubTator Score  9.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer