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Tbio
PAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Protein Summary
Description
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220597
  • ENSP00000220597
  • ENSG00000076641

Symbol
  • CBP
  • PAG
  • CBP
  • PAG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.91
hub protein
0.79
microRNA
0.77
drug perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (15)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
GAB1 signalosome
Reactome
Immune System
Reactome
Phosphorylation of CD3 and TCR zeta chains
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
GAB1 signalosome
Immune System
Phosphorylation of CD3 and TCR zeta chains
Signal Transduction
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Non-traceable Author Statement (NAS)
HGNC
Protein-Protein Interactions (131)
1 – 10 of 131
CLPB
Tbio
Family: Enzyme
Novelty: 0.00332597
p_int: 0.999977888
p_ni: 0.000022112
Data Source: BioPlex
CSK
Tchem
Family: Kinase
Novelty: 0.00233206
p_int: 0.997275623
p_ni: 0.002724376
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
GJB7
Tdark
Novelty: 0.28301887
p_int: 0.997044075
p_ni: 0.002955924
p_wrong: 1e-9
Data Source: BioPlex
CYP2S1
Tbio
Novelty: 0.04038753
p_int: 0.996551685
p_ni: 0.003447529
p_wrong: 7.86e-7
Data Source: BioPlex
ACBD7
Tdark
Novelty: 1.13055182
p_int: 0.990148026
p_ni: 0.009851971
p_wrong: 3e-9
Data Source: BioPlex
RABIF
Tbio
Novelty: 0.63157895
p_int: 0.976029409
p_ni: 0.02396174
p_wrong: 0.000008851
Data Source: BioPlex
PCDHGC3
Tbio
Novelty: 0.14681892
p_int: 0.972568958
p_ni: 0.027431042
Data Source: BioPlex
CCR1
Tchem
Family: GPCR
Novelty: 0.00293956
p_int: 0.968151208
p_ni: 0.031834441
p_wrong: 0.000014351
Score: 0.219
Data Source: BioPlex,STRINGDB
HOXB5
Tbio
Family: TF
Novelty: 0.01360604
p_int: 0.967595673
p_ni: 0.032402756
p_wrong: 0.00000157
Data Source: BioPlex
SLC25A41
Tdark
Family: Transporter
Novelty: 2.02597403
p_int: 0.963287212
p_ni: 0.036711319
p_wrong: 0.000001469
Data Source: BioPlex
Publication Statistics
PubMed Score  51.83

PubMed score by year
PubTator Score  59.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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