FKBP14
Peptidyl-prolyl cis-trans isomerase FKBP14
Protein Summary
PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens. The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012]
- ENST00000222803
- ENSP00000222803
- ENSG00000106080
- FKBP22
- EDSKMH
- FKBP22
- IPBP12
- EDSKSCL2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.73 | ||
transcription factor binding site profile | 0.71 | ||
small molecule perturbation | 0.65 | ||
cellular component | 0.6 | ||
tissue sample | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.03 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 202 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.03 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 202 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0