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Tbio
FKBP14
Peptidyl-prolyl cis-trans isomerase FKBP14

Protein Summary
Description
PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens. The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222803
  • ENSP00000222803
  • ENSG00000106080

Symbol
  • FKBP22
  • EDSKMH
  • FKBP22
  • IPBP12
  • EDSKSCL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
transcription factor binding site profile
0.71
small molecule perturbation
0.65
cellular component
0.6
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.13   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.13   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
SUN2
Tbio
Novelty:  0.01387591
p_int:  0.999995798
p_ni:  0.000004202
Data Source:  BioPlex
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.999989285
p_ni:  0.000010527
p_wrong:  1.87e-7
Data Source:  BioPlex
ST3GAL2
Tbio
Family:  Enzyme
Novelty:  0.03503891
p_int:  0.999747431
p_ni:  0.000250697
p_wrong:  0.000001872
Score:  0.179
Data Source:  BioPlex,STRINGDB
S1PR2
Tchem
Family:  GPCR
Novelty:  0.00372765
p_int:  0.999251981
p_ni:  0.000747953
p_wrong:  6.5e-8
Data Source:  BioPlex
FUT9
Tbio
Family:  Enzyme
Novelty:  0.02880554
p_int:  0.998774711
p_ni:  0.001225151
p_wrong:  1.37e-7
Score:  0.234
Data Source:  BioPlex,STRINGDB
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.998146972
p_ni:  0.001822831
p_wrong:  0.000030197
Data Source:  BioPlex
IDS
Tbio
Family:  Enzyme
Novelty:  0.00733996
p_int:  0.997839679
p_ni:  0.002160321
Data Source:  BioPlex
SPACA3
Tbio
Family:  Enzyme
Novelty:  0.04713334
p_int:  0.997768495
p_ni:  0.002231485
p_wrong:  2e-8
Data Source:  BioPlex
ERLIN2
Tbio
Novelty:  0.04060163
p_int:  0.997639124
p_ni:  0.002308611
p_wrong:  0.000052266
Score:  0.163
Data Source:  BioPlex,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.995210068
p_ni:  0.004771538
p_wrong:  0.000018395
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
IRE1alpha activates chaperones (R-HSA-381070)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
84.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
84.6
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 14
VGNC:4357
463324
Macaque
FK506 binding protein 14
696247
Mouse
MGI:2387639
231997
Rat
RGD:1311705
362366
Horse
FK506 binding protein 14
VGNC:18048
100054941
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 14
Macaque
FK506 binding protein 14
Mouse
Rat
Horse
FK506 binding protein 14
Publication Statistics
PubMed Score 43.13
PubMed score by year
PubTator Score 19.64
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title