Tchem SMOX Spermine oxidase

Protein Summary

Description

Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q9NWM0
• A2A2P5
• A2A2P6
• A8BE87
• D3DVZ4
• Q5TE26
• Q5TE27
• Q6UY28
• Q8IX00
• Q96LC3
• Q96LC4
• Q96QT3
• Q9BW38
• Q9H6H1
• Q9NP51
• Q9NPY1
• Q9NPY2

Gene Name

• SMOX

Ensembl ID

• ENST00000278795
• ENSP00000278795
• ENSG00000088826
• ENST00000305958
• ENSP00000307252
• ENST00000339123
• ENSP00000344595
• ENST00000346595
• ENSP00000341775
• ENST00000379460
• ENSP00000368773
• ENST00000621355
• ENSP00000478305

Symbol

• C20orf16
• SMO
• PAO
• SMO
• PAO1
• PAOH
• PAO-1
• PAOH1
• C20orf16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
virus perturbation	0.79
gene perturbation	0.72
transcription factor	0.72
cell line	0.6

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Dna Methyltransferase / Spermine Oxidase

Protein / Oxidoreductase / Oxidase / Spermine Oxidase

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Methyltransferase / Spermine Oxidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.85   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.85   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0