You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLTM
SAFB-like transcription modulator

Protein Summary
Description
When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.98
kinase perturbation
0.97
transcription factor binding site profile
0.89
ligand (protein) perturbation
0.83
cell type or tissue
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SAFB like transcription modulator
VGNC:6468
453475
Macaque
SAFB like transcription modulator
701841
Mouse
MGI:1913910
66660
Dog
SAFB like transcription modulator
VGNC:46514
478322
Horse
SAFB like transcription modulator
VGNC:23307
100068259
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SAFB like transcription modulator
Macaque
SAFB like transcription modulator
Mouse
Dog
SAFB like transcription modulator
Horse
SAFB like transcription modulator
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NWH9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (71)
1 – 10 of 71
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.999978745
p_ni: 0.000021255
Data Source: BioPlex
FGL1
Tbio
Novelty: 0.02650803
p_int: 0.999294691
p_ni: 0.000705309
p_wrong: 1e-9
Data Source: BioPlex
IKZF5
Tbio
Family: TF
Novelty: 0.36596327
p_int: 0.999274237
p_ni: 0.000725763
Data Source: BioPlex
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.999099401
p_ni: 0.000900599
Data Source: BioPlex
LTBR
Tbio
Novelty: 0.003823
p_int: 0.996216828
p_ni: 0.00378316
p_wrong: 1.2e-8
Data Source: BioPlex
RNH1
Tbio
Family: Enzyme
Novelty: 0.00307468
p_int: 0.967326217
p_ni: 0.032087094
p_wrong: 0.000586689
Data Source: BioPlex
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.967214662
p_ni: 0.032785041
p_wrong: 2.97e-7
Score: 0.422
Data Source: BioPlex,STRINGDB
GGPS1
Tchem
Family: Enzyme
Novelty: 0.00292258
p_int: 0.966329569
p_ni: 0.011082026
p_wrong: 0.022588405
Score: 0.239
Data Source: BioPlex,STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
p_int: 0.964959204
p_ni: 0.034714671
p_wrong: 0.000326125
Data Source: BioPlex
GHITM
Tbio
Novelty: 0.00360652
p_int: 0.964551613
p_ni: 0.018006693
p_wrong: 0.017441694
Data Source: BioPlex
Publication Statistics
PubMed Score  9.60

PubMed score by year
PubTator Score  2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer