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Tbio
SLC52A1
Solute carrier family 52, riboflavin transporter, member 1

Protein Summary
Description
Riboflavin transporter. Riboflavin transport is Na(+)-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254853
  • ENSP00000254853
  • ENSG00000132517
  • ENST00000424747
  • ENSP00000399979

Symbol
  • GPR172B
  • PAR2
  • RFT1
  • PAR2
  • RFT1
  • RBFVD
  • RFVT1
  • hRFT1
  • GPCR42
  • GPR172B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.81
tissue
0.55
cell type or tissue
0.5
cellular component
0.46
transcription factor
0.46


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.15   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.15   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
4
5
4.2
97.5
mean platelet volume
3
4
6
95.8
platelet crit
2
3
3
92.4
mean corpuscular volume
1
1
1
78.9
intraocular pressure measurement
1
2
2
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
4.2
97.5
mean platelet volume
6
95.8
platelet crit
3
92.4
mean corpuscular volume
1
78.9
intraocular pressure measurement
2
74
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 52 member 1
VGNC:9625
468169
Macaque
solute carrier family 52 member 1
711253
Mouse
MGI:1289288
52710
Rat
RGD:1560410
362942
Dog
solute carrier family 52 member 2
475125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 52 member 1
Macaque
solute carrier family 52 member 1
Mouse
Rat
Dog
solute carrier family 52 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NWF4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B2 (riboflavin) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B2 (riboflavin) metabolism
Protein-Protein Interactions (7)
1 – 7 of 7
ETFDH
Tbio
Family:  Enzyme
Novelty:  0.00970137
Score:  0.511
Data Source:  STRINGDB
FLAD1
Tbio
Family:  Enzyme
Novelty:  0.02230368
Score:  0.469
Data Source:  STRINGDB
SLC19A3
Tbio
Family:  Transporter
Novelty:  0.01200695
Score:  0.445
Data Source:  STRINGDB
ETFB
Tchem
Novelty:  0.02010772
Score:  0.424
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.413
Data Source:  STRINGDB
RFK
Tbio
Family:  Enzyme
Novelty:  0.00973729
Score:  0.408
Data Source:  STRINGDB
SLC35F2
Tbio
Family:  Transporter
Novelty:  0.08323418
Score:  0.401
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.15

PubMed score by year
PubTator Score  13.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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