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Tbio
IFT57
Intraflagellar transport protein 57 homolog

Protein Classes
Protein Summary
Description
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264538
  • ENSP00000264538
  • ENSG00000114446

Symbol
  • DERP8
  • ESRRBL1
  • HIPPI
  • HIPPI
  • OFD18
  • MHS4R2
  • ESRRBL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
histone modification site profile
0.79
gene perturbation
0.76
kinase perturbation
0.76
cellular component
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.28   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.28   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Hedgehog 'off' state
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Hedgehog 'off' state
Intraflagellar transport
Organelle biogenesis and maintenance
Signal Transduction
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (129)
1 – 10 of 129
TTC30A
Tdark
Novelty: 4
p_int: 1
Score: 0.99
Data Source: BioPlex,STRINGDB
CORO1A
Tbio
Novelty: 0.00520558
p_int: 1
Score: 0.538
Data Source: BioPlex,STRINGDB
TTC30B
Tbio
Novelty: 0.17582418
p_int: 0.999999997
p_ni: 3e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
IFT80
Tbio
Novelty: 0.07705762
p_int: 0.999999965
p_ni: 2e-9
p_wrong: 3.3e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
TRAF3IP1
Tbio
Novelty: 0.11529439
p_int: 0.9999999
p_ni: 9.2e-8
p_wrong: 8e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
IFT88
Tbio
Novelty: 0.00935043
p_int: 0.999999889
p_ni: 1.03e-7
p_wrong: 8e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
SYNE1
Tbio
Novelty: 0.00396746
p_int: 0.999999769
p_ni: 2.31e-7
Score: 0.213
Data Source: BioPlex,STRINGDB
IFT20
Tbio
Novelty: 0.03992585
p_int: 0.99999975
p_ni: 2.4e-7
p_wrong: 1e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
IFT27
Tbio
Family: Enzyme
Novelty: 0.04978515
p_int: 0.999998903
p_ni: 0.000001093
p_wrong: 5e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
COG6
Tbio
Novelty: 0.02702441
p_int: 0.99999883
p_ni: 0.00000117
Data Source: BioPlex
Publication Statistics
PubMed Score  24.28

PubMed score by year
PubTator Score  13.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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