Tbio RBFOX1 RNA binding protein fox-1 homolog 1

Protein Summary

Description

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q9NWB1
• Q7Z7I7
• Q8TAE3
• Q8TAF2
• Q8WYB2
• Q9NS20

Gene Name

• RBFOX1

Ensembl ID

• ENST00000311745
• ENSP00000309117
• ENSG00000078328
• ENST00000355637
• ENSP00000347855
• ENST00000436368
• ENSP00000402745
• ENST00000547338
• ENSP00000447717
• ENST00000550418
• ENSP00000450031
• ENST00000553186
• ENSP00000447753

Symbol

• A2BP
• A2BP1
• FOX1
• HRNBP1
• 2BP1
• FOX1
• A2BP1
• FOX-1
• HRNBP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
phenotype	0.87
transcription factor	0.83
disease	0.7
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Binding Protein Fox-1 Homolog 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Binding Protein Fox-1 Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.71   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 322   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.71   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0