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Tbio
MED9
Mediator of RNA polymerase II transcription subunit 9

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268711
  • ENSP00000268711
  • ENSG00000141026

Symbol
  • MED25
  • MED25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.66
tissue sample
0.63
interacting protein
0.61
small molecule perturbation
0.59
histone modification site profile
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
4
3
1.1
93.3
triglyceride measurement
5
4
5
90.4
BMI-adjusted waist-hip ratio
8
13
22
90.3
hip circumference
2
10
10
88.7
waist-hip ratio
5
14
16
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1.1
93.3
triglyceride measurement
5
90.4
BMI-adjusted waist-hip ratio
22
90.3
hip circumference
10
88.7
waist-hip ratio
16
85.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 9
VGNC:9373
744024
Macaque
mediator complex subunit 9
698957
Mouse
MGI:2183151
192191
Rat
RGD:1563669
497914
Dog
mediator complex subunit 9
VGNC:43142
609537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 9
Macaque
mediator complex subunit 9
Mouse
Rat
Dog
mediator complex subunit 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NWA0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Developmental Biology
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (100)
1 – 10 of 100
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.999999958
p_ni:  4.1e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
MED17
Tbio
Family:  Enzyme
Novelty:  0.02984503
p_int:  0.999999701
p_ni:  2.99e-7
Score:  0.967
Data Source:  BioPlex,STRINGDB
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.999999555
p_ni:  4.44e-7
p_wrong:  1e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  0.999998593
p_ni:  0.000001407
Score:  0.974
Data Source:  BioPlex,STRINGDB
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.999997404
p_ni:  0.000002537
p_wrong:  5.9e-8
Score:  0.944
Data Source:  BioPlex,STRINGDB
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  0.999997281
p_ni:  0.000002719
Score:  0.993
Data Source:  BioPlex,STRINGDB
MED7
Tbio
Family:  Enzyme
Novelty:  0.04773947
p_int:  0.999996759
p_ni:  0.000003239
p_wrong:  2e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
MED10
Tdark
Family:  Enzyme
Novelty:  0.02988632
p_int:  0.999996218
p_ni:  0.000003782
Score:  0.981
Data Source:  BioPlex,STRINGDB
MED28
Tbio
Family:  Enzyme
Novelty:  0.00362108
p_int:  0.999995613
p_ni:  0.000004387
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
p_int:  0.999995221
p_ni:  0.000004778
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  5.12

PubMed score by year
PubTator Score  5.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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