RBM22
Pre-mRNA-splicing factor RBM22
Protein Summary
Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]
- ENST00000199814
- ENSP00000199814
- ENSG00000086589
- ENST00000447771
- ENSP00000412118
- ZC3H16
- Cwc2
- ZC3H16
- fSAP47
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
cell type or tissue | 0.89 | ||
interacting protein | 0.88 | ||
transcription factor binding site profile | 0.85 | ||
histone modification site profile | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.69 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.69 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0