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Tdark
PLEKHJ1
Pleckstrin homology domain-containing family J member 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326631
  • ENSP00000318075
  • ENSG00000104886
  • ENST00000589097
  • ENSP00000465391

Symbol
  • GNRPX
  • GNRPX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.73
tissue sample
0.7
histone modification site profile
0.58
disease perturbation
0.56
transcription factor
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
72
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
72
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing J1
VGNC:3621
455567
Macaque
pleckstrin homology domain containing J1
710129
Mouse
MGI:1925920
78670
Rat
RGD:1307213
314634
Cow
pleckstrin homology domain containing J1
VGNC:33023
529056
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing J1
Macaque
pleckstrin homology domain containing J1
Mouse
Rat
Cow
pleckstrin homology domain containing J1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NW61-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
GOC
Protein-Protein Interactions (42)
1 – 10 of 42
PHETA2
Tbio
Novelty: 2.16796164
p_int: 0.999999999
p_ni: 1e-9
Score: 0.855
Data Source: BioPlex,STRINGDB
DENND4B
Tbio
Novelty: 1.70486718
p_int: 0.999999462
p_ni: 1.53e-7
p_wrong: 3.86e-7
Data Source: BioPlex
RTF1
Tbio
Family: Enzyme
Novelty: 0.02255644
p_int: 0.999999057
p_ni: 9.43e-7
Data Source: BioPlex
PHETA1
Tbio
Novelty: 0.52415295
p_int: 0.99999413
p_ni: 1.2e-7
p_wrong: 0.000005751
Score: 0.933
Data Source: BioPlex,STRINGDB
MLLT1
Tbio
Novelty: 0.00328241
p_int: 0.998914354
p_ni: 0.000942254
p_wrong: 0.000143391
Data Source: BioPlex
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.997730035
p_ni: 0.002269965
Data Source: BioPlex
OCRL
Tbio
Family: Enzyme
Novelty: 0.00555539
p_int: 0.994843243
p_ni: 0.005156708
p_wrong: 4.9e-8
Score: 0.874
Data Source: BioPlex,STRINGDB
DCAF16
Tdark
Novelty: 0.35666992
p_int: 0.994730609
p_ni: 0.003713688
p_wrong: 0.001555703
Data Source: BioPlex
RAB5B
Tbio
Family: Enzyme
Novelty: 0.02653775
p_int: 0.993150952
p_ni: 0.000495436
p_wrong: 0.006353613
Data Source: BioPlex
LENG8
Tdark
Novelty: 0.66682078
p_int: 0.988523477
p_ni: 0.011476511
p_wrong: 1.1e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  0.52

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer