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Tbio
FANCL
E3 ubiquitin-protein ligase FANCL

Protein Summary
Description
Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. This gene encodes a ubiquitin ligase that is a member of the Fanconi anemia complementation group (FANC). Members of this group are related by their assembly into a common nuclear protein complex rather than by sequence similarity. This gene encodes the protein for complementation group L that mediates monoubiquitination of FANCD2 as well as FANCI. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, incr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233741
  • ENSP00000233741
  • ENSG00000115392
  • ENST00000402135
  • ENSP00000385021

Symbol
  • PHF9
  • POG
  • PHF9
  • FAAP43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
histone modification site profile
0.79
transcription factor perturbation
0.74
virus perturbation
0.72
cellular component
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.25   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.25   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (134)
IL6R
Tclin
Novelty:  0.00185005
p_int:  0.999780291
p_ni:  0.000059712
p_wrong:  0.000159997
Score:  0.345
Data Source:  BioPlex,STRINGDB
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.999089219
p_ni:  0.000835419
p_wrong:  0.000075362
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.99895783
p_ni:  0.00100399
p_wrong:  0.00003818
Score:  0.179
Data Source:  BioPlex,STRINGDB
HES1
Tbio
Family:  TF
Novelty:  0.00974115
Score:  0.999
Data Source:  STRINGDB
FAAP20
Tbio
Novelty:  0.15112645
Score:  0.999
Data Source:  STRINGDB
FANCG
Tbio
Novelty:  0.00908902
Score:  0.999
Data Source:  STRINGDB
FAAP100
Tdark
Novelty:  0.1698504
Score:  0.999
Data Source:  STRINGDB
FANCM
Tbio
Novelty:  0.01122278
Score:  0.999
Data Source:  STRINGDB
CENPS
Tbio
Novelty:  0.0085893
Score:  0.999
Data Source:  STRINGDB
FANCC
Tbio
Novelty:  0.00546581
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.1
89.5
3
2
2
5.6
89.1
viral load
1
1
1
66
BMI-adjusted waist circumference
2
4
4
65.6
waist circumference
1
3
3
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
89.5
2
5.6
89.1
viral load
1
66
BMI-adjusted waist circumference
4
65.6
waist circumference
3
63.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group L
VGNC:317
459251
Macaque
Fanconi anemia complementation group L
717528
Mouse
MGI:1914280
67030
Rat
RGD:1311427
305600
Dog
FA complementation group L
VGNC:40724
612161
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group L
Macaque
Fanconi anemia complementation group L
Mouse
Rat
Dog
FA complementation group L
Publication Statistics
PubMed Score 385.25
PubMed score by year
PubTator Score 49.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title