Protein Summary
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. The transmembrane protein encoded by this gene belongs to the anoctamin family of calcium-activated chloride channels, also known as the transmembrane 16 family. The encoded protein contains eight transmembrane domains with cytosolic N- and C-termini. Defects in this gene may cause autosomal recessive spinocerebellar ataxia-10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
- ENST00000292246
- ENSP00000292246
- ENSG00000160746
- ENST00000350459
- ENSP00000327767
- ENST00000396091
- ENSP00000379398
- ENST00000414522
- ENSP00000396990
- ENST00000451430
- ENSP00000394119
- TMEM16K
- SCAR10
- TMEM16K
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.89 | ||
kinase perturbation | 0.81 | ||
transcription factor perturbation | 0.74 | ||
molecular function | 0.73 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.36 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 63 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.36 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 63 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0