Tbio RBM28 RNA-binding protein 28

Protein Summary

Description

Nucleolar component of the spliceosomal ribonucleoprotein complexes. The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9NW13
• A4D100
• B4DU52
• E9PDD9
• Q53H65
• Q96CV3

Gene Name

• RBM28

Ensembl ID

• ENST00000223073
• ENSP00000223073
• ENSG00000106344
• ENST00000415472
• ENSP00000390517

Symbol

• ANES

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.94
kinase perturbation	0.84
transcription factor perturbation	0.74
transcription factor binding site profile	0.73
tissue sample	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.98   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.98   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0