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Tbio
POLR3B
DNA-directed RNA polymerase III subunit RPC2

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. This gene encodes the se ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228347
  • ENSP00000228347
  • ENSG00000013503
  • ENST00000539066
  • ENSP00000445721

Symbol
  • C128
  • HLD8
  • RPC2
  • INMAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.94
virus perturbation
0.9
molecular function
0.7
cell line
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.98   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.98   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
78.4
self reported educational attainment
1
1
1
71.1
1
1
0
1.2
49.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
78.4
self reported educational attainment
1
71.1
0
1.2
49.2
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit B
VGNC:8502
452201
Macaque
RNA polymerase III subunit B
702711
Mouse
MGI:1917678
70428
Rat
RGD:1565311
362858
Dog
RNA polymerase III subunit B
VGNC:44801
474531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit B
Macaque
RNA polymerase III subunit B
Mouse
Rat
Dog
RNA polymerase III subunit B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NW08-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Protein-Protein Interactions (370)
1 – 10 of 370
POLR3GL
Tdark
Family: Enzyme
Novelty: 0.35648533
p_int: 0.999999793
p_ni: 2.07e-7
Score: 0.985
Data Source: BioPlex,STRINGDB
POLR3K
Tbio
Family: Enzyme
Novelty: 0.07105011
p_int: 0.999996781
p_ni: 0.000003219
Score: 0.998
Data Source: BioPlex,STRINGDB
POLR1C
Tbio
Family: Enzyme
Novelty: 0.04485332
p_int: 0.999983705
p_ni: 0.000016295
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3D
Tbio
Family: Enzyme
Novelty: 0.02616321
p_int: 0.999973189
p_ni: 0.000026811
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3E
Tbio
Family: Enzyme
Novelty: 0.06500715
p_int: 0.99991543
p_ni: 0.00008457
Score: 0.999
Data Source: BioPlex,STRINGDB
GPN3
Tbio
Family: Enzyme
Novelty: 0.13817794
p_int: 0.999018637
p_ni: 0.000981363
Score: 0.802
Data Source: BioPlex,STRINGDB
GPN1
Tbio
Family: Enzyme
Novelty: 0.06883613
p_int: 0.998836138
p_ni: 0.001163862
Score: 0.436
Data Source: BioPlex,STRINGDB
POLR2E
Tbio
Family: Enzyme
Novelty: 0.01817288
p_int: 0.998727455
p_ni: 0.001272545
Score: 0.999
Data Source: BioPlex,STRINGDB
UXT
Tbio
Novelty: 0.0272609
p_int: 0.98584214
p_ni: 0.01415786
Score: 0.814
Data Source: BioPlex,STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.952764572
p_ni: 0.047235428
Score: 0.538
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  37.98

PubMed score by year
PubTator Score  27.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer