Tdark NECAP2 Adaptin ear-binding coat-associated protein 2

Protein Summary

Description

Involved in endocytosis. This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9NVZ3
• B4DY19
• E9PGQ8
• Q5VSU4
• Q5VSU5
• Q9H7L1
• Q9H8L1

Gene Name

• NECAP2

Ensembl ID

• ENST00000337132
• ENSP00000338746
• ENSG00000157191
• ENST00000443980
• ENSP00000391942
• ENST00000457722
• ENSP00000407091
• ENST00000492095
• ENSP00000427620

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
virus perturbation	0.83
kinase perturbation	0.81
transcription factor binding site profile	0.73
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Adaptin Ear-binding Coat-associated Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0