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Tbio
NLE1
Notchless protein homolog 1

Protein Summary
Description
Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442241
  • ENSP00000413572
  • ENSG00000073536
  • ENST00000586869
  • ENSP00000466588

Symbol
  • NLE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue
0.65
biological process
0.64
cellular component
0.64
histone modification site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.04   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.04   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
17
40.7
macrophage inflammatory protein 1b measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
17
40.7
macrophage inflammatory protein 1b measurement
1
13.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
notchless homolog 1
VGNC:49006
468214
Macaque
notchless homolog 1
715324
Mouse
MGI:2429770
217011
Rat
RGD:1308301
303372
Dog
notchless homolog 1
VGNC:43838
491142
Species
Name
OMA
EggNOG
Inparanoid
Chimp
notchless homolog 1
Macaque
notchless homolog 1
Mouse
Rat
Dog
notchless homolog 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NVX2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (316)
1 – 10 of 316
NSA2
Tbio
Novelty:  0.04542275
p_int:  0.999558279
p_ni:  0.000441721
Score:  0.995
Data Source:  BioPlex,STRINGDB
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.998989135
p_ni:  0.001010865
Score:  0.353
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.992258501
p_ni:  0.007741498
p_wrong:  1e-9
Score:  0.548
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.988821979
p_ni:  0.011178019
p_wrong:  2e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.988783153
p_ni:  0.011216843
p_wrong:  5e-9
Score:  0.151
Data Source:  BioPlex,STRINGDB
IGHMBP2
Tbio
Novelty:  0.01054517
p_int:  0.987602814
p_ni:  0.012397183
p_wrong:  3e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
RPL15
Tbio
Novelty:  0.02466708
p_int:  0.98568703
p_ni:  0.014312964
p_wrong:  6e-9
Score:  0.754
Data Source:  BioPlex,STRINGDB
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.976188983
p_ni:  0.02380963
p_wrong:  0.000001387
Score:  0.301
Data Source:  BioPlex,STRINGDB
GNL3
Tbio
Novelty:  0.00886703
p_int:  0.958443574
p_ni:  0.04151377
p_wrong:  0.000042655
Score:  0.961
Data Source:  BioPlex,STRINGDB
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.948124998
p_ni:  0.051870674
p_wrong:  0.000004328
Data Source:  BioPlex
Publication Statistics
PubMed Score  29.04

PubMed score by year
PubTator Score  7.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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