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Tbio
RLIM
E3 ubiquitin-protein ligase RLIM

Protein Summary
Description
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332687
  • ENSP00000328059
  • ENSG00000131263
  • ENST00000349225
  • ENSP00000253571

Symbol
  • RNF12
  • MRX61
  • RNF12
  • TOKAS
  • NY-REN-43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor binding site profile
0.87
virus perturbation
0.85
microRNA
0.76
small molecule perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.75   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.75   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (316)
1 – 10 of 316
CITED1
Tbio
Novelty: 0.01956689
p_int: 0.98929599
p_ni: 0.01070401
Data Source: BioPlex
DNAJB2
Tbio
Novelty: 0.046216
p_int: 0.896668229
p_ni: 0.103331771
Score: 0.345
Data Source: BioPlex,STRINGDB
UPF3B
Tbio
Novelty: 0.03482348
p_int: 0.750994888
p_ni: 0.24900504
p_wrong: 7.2e-8
Score: 0.474
Data Source: BioPlex,STRINGDB
UBE2D1
Tbio
Novelty: 0.00865867
Score: 0.971
Data Source: STRINGDB
UBE2E2
Tbio
Novelty: 0.02752227
Score: 0.961
Data Source: STRINGDB
LNX1
Tbio
Family: Enzyme
Novelty: 0.01555905
Score: 0.96
Data Source: STRINGDB
SMURF2
Tbio
Family: Enzyme
Novelty: 0.00920984
Score: 0.952
Data Source: STRINGDB
SIAH1
Tbio
Family: Enzyme
Novelty: 0.00831224
Score: 0.951
Data Source: STRINGDB
UBE2H
Tbio
Novelty: 0.03259425
Score: 0.949
Data Source: STRINGDB
UBE2O
Tbio
Novelty: 0.07084123
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.75

PubMed score by year
PubTator Score  19.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer