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Tbio
POLR3E
DNA-directed RNA polymerase III subunit RPC5

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299853
  • ENSP00000299853
  • ENSG00000058600
  • ENST00000359210
  • ENSP00000352140
  • ENST00000418581
  • ENSP00000399254
  • ENST00000564209
  • ENSP00000456967
  • ENST00000638476
  • ENSP00000492534
  • ENSG00000284282
  • ENST00000638525
  • ENSP00000492639
  • ENST00000639149
  • ENSP00000492586
  • ENST00000640588
  • ENSP00000492263

Symbol
  • KIAA1452
  • SIN
  • RPC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
kinase perturbation
0.91
interacting protein
0.89
transcription factor perturbation
0.8
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.16   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.16   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (17)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (144)
1 – 10 of 144
POLR3D
Tbio
Family: Enzyme
Novelty: 0.03502574
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
POLR3GL
Tbio
Family: Enzyme
Novelty: 0.03131524
p_int: 0.999999897
p_ni: 1.03e-7
Score: 0.985
Data Source: BioPlex,STRINGDB
POLR1C
Tbio
Family: Enzyme
Novelty: 0.02674163
p_int: 0.99999978
p_ni: 2.2e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
GPN3
Tbio
Family: Enzyme
Novelty: 0.25531915
p_int: 0.999998952
p_ni: 0.000001048
Score: 0.69
Data Source: BioPlex,STRINGDB
POLR3G
Tbio
Family: Enzyme
Novelty: 0.058744
p_int: 0.99999489
p_ni: 0.000004084
p_wrong: 0.000001026
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3H
Tbio
Family: Enzyme
Novelty: 0.04474273
p_int: 0.999994841
p_ni: 0.00000468
p_wrong: 4.8e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3F
Tbio
Family: Enzyme
Novelty: 0.13846534
p_int: 0.999964292
p_ni: 0.000035699
p_wrong: 8e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3C
Tbio
Family: Enzyme
Novelty: 0.1416566
p_int: 0.999955885
p_ni: 0.000044114
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR2E
Tbio
Family: Enzyme
Novelty: 0.02478824
p_int: 0.999924206
p_ni: 0.000075794
Score: 0.998
Data Source: BioPlex,STRINGDB
POLR3B
Tbio
Family: Enzyme
Novelty: 0.05095277
p_int: 0.99991543
p_ni: 0.00008457
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  130.16

PubMed score by year
PubTator Score  67.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer