PNPO
Pyridoxine-5'-phosphate oxidase
Protein Summary
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008]
- ENST00000225573
- ENSP00000225573
- ENSG00000108439
- ENST00000434554
- ENSP00000399960
- ENST00000582171
- ENSP00000463994
- ENST00000585320
- ENSP00000462345
- ENST00000641856
- ENSP00000493224
- ENST00000642017
- ENSP00000493302
- PDXPO
- HEL-S-302
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.88 | ||
transcription factor perturbation | 0.84 | ||
histone modification site profile | 0.8 | ||
disease perturbation | 0.79 | ||
virus perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.76 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 322 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.76 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 322 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0