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Tdark
MRPS18A
39S ribosomal protein S18a, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372116
  • ENSP00000361188
  • ENSG00000096080
  • ENST00000372133
  • ENSP00000361206

Symbol
  • S18bmt
  • S18mt-a
  • MRPS18-3
  • HumanS18b
  • MRP-S18-3
  • MRP-S18-a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
histone modification site profile
0.78
cellular component
0.77
transcription factor binding site profile
0.77
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
42.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
42.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S18A
VGNC:3492
462723
Macaque
mitochondrial ribosomal protein S18A
701465
Mouse
MGI:1915815
68565
Rat
RGD:735229
301249
Dog
mitochondrial ribosomal protein S18A
VGNC:43412
474917
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S18A
Macaque
mitochondrial ribosomal protein S18A
Mouse
Rat
Dog
mitochondrial ribosomal protein S18A
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NVS2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (198)
1 – 10 of 198
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.999793803
p_ni: 0.000206197
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.99951732
p_ni: 0.00048268
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.999474807
p_ni: 0.000525193
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999443628
p_ni: 0.000556372
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.99926788
p_ni: 0.00073212
Score: 0.989
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.997593675
p_ni: 0.002406325
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.997049014
p_ni: 0.002950986
Score: 0.981
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.994227013
p_ni: 0.005772987
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL39
Tbio
Novelty: 0.14346457
p_int: 0.969236085
p_ni: 0.030763915
Score: 0.989
Data Source: BioPlex,STRINGDB
RPL37
Tbio
Novelty: 0.03935854
p_int: 0.956613697
p_ni: 0.043386303
Data Source: BioPlex
Publication Statistics
PubMed Score  3.53

PubMed score by year
PubTator Score  0.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer