Tbio FAIM Fas apoptotic inhibitory molecule 1

Protein Summary

Description

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• Q9NVQ4
• Q6IAN2

Gene Name

• FAIM

Ensembl ID

• ENST00000338446
• ENSP00000342805
• ENSG00000158234
• ENST00000360570
• ENSP00000353775
• ENST00000393034
• ENSP00000376754
• ENST00000393035
• ENSP00000376755
• ENST00000464668
• ENSP00000417642

Symbol

• FAIM1
• FAIM1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
cell type or tissue	0.8
histone modification site profile	0.77
tissue sample	0.66
gene perturbation	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.29   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 314   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.29   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0