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Tbio
ASF1B
Histone chaperone ASF1B

Protein Summary
Description
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263382
  • ENSP00000263382
  • ENSG00000105011

Symbol
  • CIA-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor binding site profile
0.87
histone modification site profile
0.73
transcription factor perturbation
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.47   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.47   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (305)
CDAN1
Tbio
Novelty:  0.00610604
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.707
Data Source:  BioPlex,STRINGDB
C15orf41
Tbio
Novelty:  0.11812699
p_int:  0.999999995
p_ni:  2e-9
p_wrong:  3e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
CABIN1
Tbio
Novelty:  0.02528794
p_int:  0.99999999
p_ni:  9e-9
Score:  0.574
Data Source:  BioPlex,STRINGDB
UBN1
Tbio
Novelty:  0.01703683
p_int:  0.999999989
p_ni:  3e-9
p_wrong:  8e-9
Score:  0.483
Data Source:  BioPlex,STRINGDB
UBN2
Tbio
Novelty:  0.09777456
p_int:  0.999999983
p_ni:  1.7e-8
p_wrong:  1e-9
Score:  0.266
Data Source:  BioPlex,STRINGDB
HIRA
Tbio
Novelty:  0.01362595
p_int:  0.999999957
p_ni:  2e-8
p_wrong:  2.3e-8
Score:  0.921
Data Source:  BioPlex,STRINGDB
PAN3
Tdark
Family:  Kinase
Novelty:  3.36673347
p_int:  0.999999783
p_ni:  2.17e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
TLK1
Tchem
Family:  Kinase
Novelty:  0.0342719
p_int:  0.999999512
p_ni:  4.88e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
PAN2
Tbio
Family:  Enzyme
Novelty:  0.1195117
p_int:  0.999999187
p_ni:  2.69e-7
p_wrong:  5.45e-7
Score:  0.291
Data Source:  BioPlex,STRINGDB
TONSL
Tbio
Novelty:  0.07220129
p_int:  0.999997825
p_ni:  0.000002174
Score:  0.739
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
62.1
lymphocyte count
1
1
1
58.4
reticulocyte count
2
2
2
56.6
lymphocyte percentage of leukocytes
1
1
1
53.7
sex hormone-binding globulin measurement
2
1
2
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
62.1
lymphocyte count
1
58.4
reticulocyte count
2
56.6
lymphocyte percentage of leukocytes
1
53.7
sex hormone-binding globulin measurement
2
40.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anti-silencing function 1B histone chaperone
VGNC:11224
748025
Macaque
anti-silencing function 1B histone chaperone
717646
Mouse
MGI:1914179
66929
Rat
RGD:1304918
304648
Dog
anti-silencing function 1B histone chaperone
484905
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anti-silencing function 1B histone chaperone
Macaque
anti-silencing function 1B histone chaperone
Mouse
Rat
Dog
anti-silencing function 1B histone chaperone
Publication Statistics
PubMed Score 22.47
PubMed score by year
PubTator Score 11.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title