Tbio RIC8B Synembryn-B

Protein Summary

Description

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

Uniprot Accession IDs

• Q9NVN3
• A2RTZ0
• Q4G103
• Q6ZRN4
• Q86WD3

Gene Name

• RIC8B

Ensembl ID

• ENST00000355478
• ENSP00000347662
• ENSG00000111785
• ENST00000392839
• ENSP00000376583
• ENST00000462949
• ENSP00000435301
• ENST00000470960
• ENSP00000436359
• ENST00000638198
• ENSP00000492690

Symbol

• RIC8
• hSyn

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.92
histone modification site profile	0.86
cell type or tissue	0.76
microRNA	0.69
tissue	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.11   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.11   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0