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Tbio
INTS13
Integrator complex subunit 13

Protein Summary
Description
Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261191
  • ENSP00000261191
  • ENSG00000064102

Symbol
  • ASUN
  • C12orf11
  • GCT1
  • ASUN
  • GCT1
  • NET48
  • Mat89Bb
  • SPATA30
  • C12orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
1
1
62.1
basophil count
2
1
2
52
1
1
1
49.5
mean corpuscular volume
1
1
1
26.1
mean corpuscular hemoglobin concentration
1
1
1
10.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
62.1
basophil count
2
52
1
49.5
mean corpuscular volume
1
26.1
mean corpuscular hemoglobin concentration
1
10.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 13
VGNC:8341
465353
Macaque
integrator complex subunit 13
708806
Mouse
MGI:1918427
71177
Rat
RGD:1592236
690728
Dog
integrator complex subunit 13
VGNC:42049
486627
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 13
Macaque
integrator complex subunit 13
Mouse
Rat
Dog
integrator complex subunit 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NVM9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (96)
1 – 10 of 96
INTS10
Tbio
Novelty:  0.15415606
p_int:  1
Score:  0.964
Data Source:  BioPlex,STRINGDB
HOPX
Tbio
Family:  TF
Novelty:  0.00415501
p_int:  0.993723063
p_ni:  0.001438061
p_wrong:  0.004838876
Score:  0.692
Data Source:  BioPlex,STRINGDB
INTS1
Tbio
Novelty:  0.17523407
Score:  0.999
Data Source:  STRINGDB
INTS3
Tbio
Novelty:  0.13398603
Score:  0.999
Data Source:  STRINGDB
INTS6
Tbio
Novelty:  0.02680242
Score:  0.999
Data Source:  STRINGDB
INTS5
Tbio
Novelty:  0.02127142
Score:  0.999
Data Source:  STRINGDB
INTS2
Tdark
Novelty:  0.22178745
Score:  0.995
Data Source:  STRINGDB
INTS7
Tdark
Novelty:  0.04592325
Score:  0.992
Data Source:  STRINGDB
INTS4
Tdark
Novelty:  0.20868831
Score:  0.991
Data Source:  STRINGDB
INTS14
Tdark
Novelty:  1.33783374
Score:  0.989
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.55

PubMed score by year
PubTator Score  5.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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