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Tbio
ARL8B
ADP-ribosylation factor-like protein 8B

Protein Summary
Description
May play a role in lysosome motility (PubMed:16537643, PubMed:25898167). May play a role in chromosome segregation (PubMed:15331635).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256496
  • ENSP00000256496
  • ENSG00000134108
  • ENST00000419534
  • ENSP00000402996
  • ENST00000611208
  • ENSP00000479202

Symbol
  • ARL10C
  • GIE1
  • Gie1
  • ARL10C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.96
transcription factor perturbation
0.96
interacting protein
0.91
transcription factor binding site profile
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.02   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.02   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.999999484
p_ni:  7.9e-8
p_wrong:  4.36e-7
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.989512908
p_ni:  0.010288045
p_wrong:  0.000199046
Data Source:  BioPlex
SDF4
Tbio
Novelty:  0.00105893
p_int:  0.967442147
p_ni:  0.032557852
p_wrong:  1e-9
Data Source:  BioPlex
SGO2
Tbio
Novelty:  0.05544423
p_int:  0.960848058
p_ni:  0.039151942
Data Source:  BioPlex
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.958103253
p_ni:  0.041896729
p_wrong:  1.8e-8
Data Source:  BioPlex
PMEL
Tclin
Novelty:  0.00116525
p_int:  0.935731715
p_ni:  0.064268281
p_wrong:  4e-9
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.933056976
p_ni:  0.066943024
Data Source:  BioPlex
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.931738155
p_ni:  0.06826184
p_wrong:  5e-9
Data Source:  BioPlex
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.931464192
p_ni:  0.068535774
p_wrong:  3.4e-8
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.927669771
p_ni:  0.072330194
p_wrong:  3.5e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
39.7
balding measurement
1
1
1
5.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
39.7
balding measurement
1
5.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 8B
VGNC:7030
738415
Macaque
ADP ribosylation factor like GTPase 8B
703201
Mouse
MGI:1914416
67166
Rat
RGD:1562830
500282
Dog
ADP ribosylation factor like GTPase 8B
VGNC:38122
612944
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 8B
Macaque
ADP ribosylation factor like GTPase 8B
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 8B
Publication Statistics
PubMed Score 25.02
PubMed score by year
PubTator Score 10.50
PubTator score by year
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Related Publications
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PMID
Year
Title