You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FANCI
Fanconi anemia group I protein

Protein Summary
Description
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300027
  • ENSP00000300027
  • ENSG00000140525
  • ENST00000310775
  • ENSP00000310842
  • ENST00000567996
  • ENSP00000458024

Symbol
  • KIAA1794
  • KIAA1794
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
0.97
virus perturbation
0.95
histone modification site profile
0.9
co-expressed gene
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.62   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.62   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
1
3
0
76.4
82.8
red blood cell distribution width
2
2
2
80.7
body height
1
1
1
59.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
0
76.4
82.8
red blood cell distribution width
2
80.7
body height
1
59.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group I
VGNC:3553
453636
Macaque
Fanconi anemia complementation group I
699878
Mouse
MGI:2384790
208836
Rat
RGD:2321863
100360594
Dog
FA complementation group I
VGNC:40723
100856370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group I
Macaque
Fanconi anemia complementation group I
Mouse
Rat
Dog
FA complementation group I
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NVI1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (304)
1 – 10 of 304
FCER1A
Tbio
Novelty: 0.00362182
p_int: 0.812141736
p_ni: 0.187858264
Data Source: BioPlex
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.781869742
p_ni: 0.218130258
Data Source: BioPlex
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.765998782
p_ni: 0.234001218
Data Source: BioPlex
FANCD2
Tbio
Novelty: 0.00316101
Score: 0.999
Data Source: Reactome,STRINGDB
FANCL
Tbio
Family: Enzyme
Novelty: 0.00274467
Score: 0.997
Data Source: STRINGDB
FANCM
Tbio
Novelty: 0.01122278
Score: 0.995
Data Source: STRINGDB
FANCA
Tbio
Novelty: 0.00324947
Score: 0.994
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.994
Data Source: STRINGDB
BRCA2
Tbio
Novelty: 0.0002217
Score: 0.993
Data Source: STRINGDB
FANCB
Tbio
Novelty: 0.00268111
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.62

PubMed score by year
PubTator Score  49.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer