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Tdark
INTS7
Integrator complex subunit 7

Protein Summary
Description
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366992
  • ENSP00000355959
  • ENSG00000143493
  • ENST00000366993
  • ENSP00000355960
  • ENST00000366994
  • ENSP00000355961
  • ENST00000440600
  • ENSP00000388908

Symbol
  • C1orf73
  • INT7
  • C1orf73
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.91
histone modification site profile
0.82
disease perturbation
0.74
virus perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.28   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.28   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
CD226
Tbio
Novelty:  0.00374102
p_int:  0.99982139
p_ni:  0.00017861
Data Source:  BioPlex
VSIG4
Tbio
Novelty:  0.01671671
p_int:  0.999291613
p_ni:  0.000708387
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.998166145
p_ni:  0.00183381
p_wrong:  4.5e-8
Data Source:  BioPlex
TMEFF1
Tbio
Novelty:  0.11856207
p_int:  0.996027509
p_ni:  0.00397249
p_wrong:  1e-9
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.994474131
p_ni:  0.005525862
p_wrong:  7e-9
Data Source:  BioPlex
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.994385658
p_ni:  0.005612749
p_wrong:  0.000001593
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.991181982
p_ni:  0.008818018
Data Source:  BioPlex
KCNE1
Tchem
Family:  IC
Novelty:  0.0015463
p_int:  0.990968852
p_ni:  0.009031148
Data Source:  BioPlex
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.975254784
p_ni:  0.024745133
p_wrong:  8.3e-8
Data Source:  BioPlex
FNDC4
Tbio
Novelty:  0.31597146
p_int:  0.967183123
p_ni:  0.032812671
p_wrong:  0.000004205
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

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1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
2
3
85.6
body height
1
1
1
48.7
BMI-adjusted hip circumference
1
1
1
26.6
electrocardiography
1
1
2
21.2
platelet crit
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
85.6
body height
1
48.7
BMI-adjusted hip circumference
1
26.6
electrocardiography
2
21.2
platelet crit
1
20.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 7
VGNC:1273
457715
Macaque
integrator complex subunit 7
711152
Mouse
MGI:1924315
77065
Rat
RGD:1308014
289382
Dog
integrator complex subunit 7
VGNC:42056
490278
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 7
Macaque
integrator complex subunit 7
Mouse
Rat
Dog
integrator complex subunit 7
Publication Statistics
PubMed Score 44.28
PubMed score by year
PubTator Score 6.78
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title