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Tbio
DNAJC11
DnaJ homolog subfamily C member 11

Protein Summary
Description
Isoform 1: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294401
  • ENSP00000294401
  • ENSG00000007923
  • ENST00000377577
  • ENSP00000366800

Symbol
  • dJ126A5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
disease perturbation
0.9
histone modification site profile
0.76
tissue sample
0.72
transcription factor
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
70.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C11
VGNC:6781
745844
Macaque
dnaJ homolog subfamily C member 11
705057
Mouse
MGI:2443386
230935
Rat
RGD:1307731
362666
Dog
DnaJ heat shock protein family (Hsp40) member C11
VGNC:53345
612784
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C11
Macaque
dnaJ homolog subfamily C member 11
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NVH1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (73)
1 – 10 of 73
ARMC1
Tbio
Novelty: 0.02018109
p_int: 0.990136884
p_ni: 0.009863116
Score: 0.156
Data Source: BioPlex,STRINGDB
SUOX
Tbio
Family: Enzyme
Novelty: 0.00971136
p_int: 0.985986054
p_ni: 0.014013946
Score: 0.215
Data Source: BioPlex,STRINGDB
RNF214
Tdark
Novelty: 2.76722057
p_int: 0.962127693
p_ni: 0.037872307
Score: 0.309
Data Source: BioPlex,STRINGDB
PDE6D
Tclin
Family: Enzyme
Novelty: 0.02276328
p_int: 0.954569284
p_ni: 0.045392298
p_wrong: 0.000038418
Score: 0.228
Data Source: BioPlex,STRINGDB
FAM174A
Tdark
Novelty: 0.30693139
p_int: 0.941069986
p_ni: 0.058930014
Data Source: BioPlex
TRABD
Tdark
Novelty: 0.47132923
p_int: 0.939075803
p_ni: 0.060924196
Score: 0.188
Data Source: BioPlex,STRINGDB
WDR73
Tbio
Novelty: 0.10253438
p_int: 0.912660803
p_ni: 0.087339096
p_wrong: 1e-7
Score: 0.295
Data Source: BioPlex,STRINGDB
YTHDF1
Tbio
Novelty: 0.02063275
p_int: 0.893988418
p_ni: 0.106011581
Score: 0.159
Data Source: BioPlex,STRINGDB
TAX1BP1
Tbio
Novelty: 0.02498501
p_int: 0.875177935
p_ni: 0.124822057
p_wrong: 9e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
MCOLN3
Tchem
Family: IC
Novelty: 0.03209262
p_int: 0.860003887
p_ni: 0.139996113
Data Source: BioPlex
Publication Statistics
PubMed Score  3.22

PubMed score by year
PubTator Score  1.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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