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Tbio
EXD2
Exonuclease 3'-5' domain-containing protein 2

Protein Summary
Description
Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312994
  • ENSP00000313140
  • ENSG00000081177
  • ENST00000409014
  • ENSP00000386915
  • ENST00000409018
  • ENSP00000387331
  • ENST00000409242
  • ENSP00000386839
  • ENST00000409675
  • ENSP00000386762
  • ENST00000409949
  • ENSP00000386632

Symbol
  • C14orf114
  • EXDL2
  • EXDL2
  • C14orf114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
histone modification site profile
0.87
transcription factor perturbation
0.84
cell type or tissue
0.67
tissue sample
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.17   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.17   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
1
2
62.6
1
1
1
57.6
unipolar depression
1
1
1
57.6
self reported educational attainment
1
1
1
57.6
neuroticism measurement
2
1
1
6
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
62.6
1
57.6
unipolar depression
1
57.6
self reported educational attainment
1
57.6
neuroticism measurement
1
6
26.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exonuclease 3'-5' domain containing 2
VGNC:8200
452996
Macaque
exonuclease 3'-5' domain containing 2
712296
Mouse
MGI:1922485
97827
Rat
RGD:1311087
362759
Dog
exonuclease 3'-5' domain containing 2
VGNC:40509
490750
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exonuclease 3'-5' domain containing 2
Macaque
exonuclease 3'-5' domain containing 2
Mouse
Rat
Dog
exonuclease 3'-5' domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NVH0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (79)
1 – 10 of 79
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.99995152
p_ni: 0.00004848
Data Source: BioPlex
GRAMD2B
Tdark
Novelty: 0.55744753
p_int: 0.999934441
p_ni: 0.000065559
Score: 0.201
Data Source: BioPlex,STRINGDB
NME3
Tbio
Family: Kinase
Novelty: 0.05947052
p_int: 0.996652702
p_ni: 0.003347298
Score: 0.206
Data Source: BioPlex,STRINGDB
EVL
Tbio
Novelty: 0.03533257
p_int: 0.989285612
p_ni: 0.010714388
Score: 0.163
Data Source: BioPlex,STRINGDB
ASPH
Tbio
Family: Enzyme
Novelty: 0.00291455
p_int: 0.913628
p_ni: 0.086372
Data Source: BioPlex
DCTN2
Tbio
Novelty: 0.01045432
p_int: 0.881328131
p_ni: 0.118671869
Score: 0.207
Data Source: BioPlex,STRINGDB
CLPX
Tbio
Family: Enzyme
Novelty: 0.00254331
p_int: 0.759661928
p_ni: 0.240338072
Score: 0.209
Data Source: BioPlex,STRINGDB
TMEM214
Tdark
Novelty: 0.32604613
Score: 0.909
Data Source: STRINGDB
CNOT2
Tbio
Novelty: 0.01886737
Score: 0.818
Data Source: STRINGDB
SEC61B
Tbio
Novelty: 0.08622222
Score: 0.811
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.17

PubMed score by year
PubTator Score  7.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer