Tbio PANK4 Pantothenate kinase 4

Protein Summary

Description

Plays a role in the physiological regulation of the intracellular CoA concentration. This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NVE7
• B9DI84
• Q53EU3
• Q5TA84
• Q7RTX3
• Q9H3X5
• hPanK4

Gene Name

• PANK4

Ensembl ID

• ENST00000378466
• ENSP00000367727
• ENSG00000157881
• ENST00000615291
• ENSP00000478189
• ENSG00000273494

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
molecular function	0.88
transcription factor binding site profile	0.73
disease perturbation	0.68
kinase perturbation	0.66

Protein Classes

DTO Classes

Protein / Kinase / Unclassified Protein / Pantothenate Kinase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0