Tbio PARVA Alpha-parvin

Protein Summary

Description

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q9NVD7
• Q96C85
• Q9HA48

Gene Name

• PARVA

Ensembl ID

• ENST00000334956
• ENSP00000334008
• ENSG00000197702

Symbol

• MXRA2
• MXRA2
• CH-ILKBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
virus perturbation	1
trait	0.97
interacting protein	0.91
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Alpha-parvin

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Alpha-parvin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.12   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0