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Tbio
MED17
Mediator of RNA polymerase II transcription subunit 17

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251871
  • ENSP00000251871
  • ENSG00000042429

Symbol
  • ARC77
  • CRSP6
  • DRIP77
  • DRIP80
  • TRAP80
  • SRB4
  • CRSP6
  • CRSP77
  • DRIP80
  • TRAP80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.92
virus perturbation
0.92
transcription factor binding site profile
0.85
protein complex
0.8
co-expressed gene
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.91   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.91   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
MED27
Tbio
Family:  Enzyme
Novelty:  0.02511389
p_int:  0.999999964
p_ni:  3.6e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  0.999999833
p_ni:  1.67e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
MED6
Tbio
Family:  Enzyme
Novelty:  0.05215086
p_int:  0.999999763
p_ni:  2.37e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
MED30
Tbio
Family:  Enzyme
Novelty:  0.08618054
p_int:  0.999999761
p_ni:  2.39e-7
Score:  0.996
Data Source:  BioPlex,STRINGDB
MED13L
Tbio
Family:  Enzyme
Novelty:  0.03766796
p_int:  0.999999757
p_ni:  2.43e-7
Score:  0.953
Data Source:  BioPlex,STRINGDB
MED8
Tbio
Family:  Enzyme
Novelty:  0.06648307
p_int:  0.999999745
p_ni:  2.55e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
MED24
Tbio
Family:  Enzyme
Novelty:  0.05466084
p_int:  0.999999719
p_ni:  2.82e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
MED9
Tbio
Family:  Enzyme
Novelty:  0.19660296
p_int:  0.999999701
p_ni:  2.99e-7
Score:  0.967
Data Source:  BioPlex,STRINGDB
MED12L
Tdark
Family:  Enzyme
Novelty:  0.09658419
p_int:  0.999999695
p_ni:  3.05e-7
Score:  0.855
Data Source:  BioPlex,STRINGDB
MED28
Tbio
Family:  Enzyme
Novelty:  0.00362108
p_int:  0.999999666
p_ni:  3.34e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1
2
71.9
smoking status measurement
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
71.9
smoking status measurement
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 17
VGNC:1108
451486
Macaque
mediator complex subunit 17
696725
Mouse
MGI:2182585
234959
Rat
RGD:1311120
300367
Dog
mediator complex subunit 17
VGNC:52266
476769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 17
Macaque
mediator complex subunit 17
Mouse
Rat
Dog
mediator complex subunit 17
Publication Statistics
PubMed Score 36.91
PubMed score by year
PubTator Score 23.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title