Tbio MED17 Mediator of RNA polymerase II transcription subunit 17

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NVC6
• B3KN07
• Q9HA81
• Q9UNP7
• Q9Y2W0
• Q9Y660

Gene Name

• MED17

Ensembl ID

• ENST00000251871
• ENSP00000251871
• ENSG00000042429

Symbol

• ARC77
• CRSP6
• DRIP77
• DRIP80
• TRAP80
• SRB4
• CRSP6
• CRSP77
• DRIP80
• TRAP80

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.92
virus perturbation	0.92
transcription factor binding site profile	0.85
protein complex	0.8
co-expressed gene	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.91   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.91   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (133)

Explore Interacting Targets

1 – 10 of 133

• See Interactions on String-DB

MED27

Tbio

Family:  Enzyme

Novelty:  0.02511389

p_int:  0.999999964

p_ni:  3.6e-8

Score:  0.998

Data Source:  BioPlex,STRINGDB

MED19

Tbio

Family:  Enzyme

Novelty:  0.03926689

p_int:  0.999999833

p_ni:  1.67e-7

Score:  0.998

Data Source:  BioPlex,STRINGDB

MED6

Tbio

Family:  Enzyme

Novelty:  0.05215086

p_int:  0.999999763

p_ni:  2.37e-7

Score:  0.998

Data Source:  BioPlex,STRINGDB

MED30

Tbio

Family:  Enzyme

Novelty:  0.08618054

p_int:  0.999999761

p_ni:  2.39e-7

Score:  0.996

Data Source:  BioPlex,STRINGDB

MED13L

Tbio

Family:  Enzyme

Novelty:  0.03766796

p_int:  0.999999757

p_ni:  2.43e-7

Score:  0.953

Data Source:  BioPlex,STRINGDB

MED8

Tbio

Family:  Enzyme

Novelty:  0.06648307

p_int:  0.999999745

p_ni:  2.55e-7

Score:  0.998

Data Source:  BioPlex,STRINGDB

MED24

Tbio

Family:  Enzyme

Novelty:  0.05466084

p_int:  0.999999719

p_ni:  2.82e-7

Score:  0.994

Data Source:  BioPlex,STRINGDB

MED9

Tbio

Family:  Enzyme

Novelty:  0.19660296

p_int:  0.999999701

p_ni:  2.99e-7

Score:  0.967

Data Source:  BioPlex,STRINGDB

MED12L

Tdark

Family:  Enzyme

Novelty:  0.09658419

p_int:  0.999999695

p_ni:  3.05e-7

Score:  0.855

Data Source:  BioPlex,STRINGDB

MED28

Tbio

Family:  Enzyme

Novelty:  0.00362108

p_int:  0.999999666

p_ni:  3.34e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (9)

KEGG (1)

Developmental Biology (R-HSA-1266738)

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5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (6)

Components (6)

Processes (6)

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1 – 6 of 6

GO Term	Evidence	Assigned by
signaling receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
thyroid hormone receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription coactivator activity	Inferred from Direct Assay (IDA)	MGI
transcription coregulator activity	Inferred from Direct Assay (IDA)	UniProtKB
nuclear receptor transcription coactivator activity	Non-traceable Author Statement (NAS)	UniProtKB
vitamin D receptor binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	1	1	2		71.9
smoking status measurement	EFO_0006527	1	1	1		26.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	2		71.9
smoking status measurement	EFO_0006527	1		26.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Activator
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Nucleus
Polymorphism
Reference proteome
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
smoking status measurement

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mediator complex subunit 17	VGNC:1108	451486
Macaque	mediator complex subunit 17		696725
Mouse	mediator complex subunit 17	MGI:2182585	234959
Rat	mediator complex subunit 17	RGD:1311120	300367
Dog	mediator complex subunit 17	VGNC:52266	476769

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mediator complex subunit 17
Macaque	mediator complex subunit 17
Mouse	mediator complex subunit 17
Rat	mediator complex subunit 17
Dog	mediator complex subunit 17

Publication Statistics

PubMed Score 36.91

PubMed score by year

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PubTator Score 23.85

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (6)

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10

0 of 0

PMID	Year	Title