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Tbio
UQCC1
Ubiquinol-cytochrome-c reductase complex assembly factor 1

Protein Summary
Description
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability. This gene encodes a transmembrane protein that is structurally similar to the mouse basic fibroblast growth factor repressed ZIC-binding protein. In mouse this protein may be involved in fibroblast growth factor regulated growth control. In humans, polymorphisms in this gene are associated with variation in human height and osteoarthritis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349714
  • ENSP00000335364
  • ENSG00000101019
  • ENST00000374380
  • ENSP00000363501
  • ENST00000374384
  • ENSP00000363505
  • ENST00000374385
  • ENSP00000363506

Symbol
  • BZFB
  • C20orf44
  • UQCC
  • BFZB
  • CBP3
  • UQCC
  • C20orf44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor perturbation
0.8
cell type or tissue
0.78
transcription factor binding site profile
0.69
transcription factor
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.86   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.86   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
4
8
99.1
body height
7
5
11
98.7
BMI-adjusted waist-hip ratio
8
4
10
94.4
suntan
1
1
1
87.6
waist-hip ratio
2
1
2
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
8
99.1
body height
11
98.7
BMI-adjusted waist-hip ratio
10
94.4
suntan
1
87.6
waist-hip ratio
2
87
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase complex assembly factor 1
VGNC:10061
458201
Macaque
ubiquinol-cytochrome-c reductase complex assembly factor 1
705546
Mouse
MGI:1929472
56046
Rat
RGD:1585681
683512
Dog
ubiquinol-cytochrome c reductase complex assembly factor 1
VGNC:48159
608882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase complex assembly factor 1
Macaque
ubiquinol-cytochrome-c reductase complex assembly factor 1
Mouse
Rat
Dog
ubiquinol-cytochrome c reductase complex assembly factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NVA1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ciliary landscape
WikiPathways
Ciliary landscape
WikiPathways
Breast cancer pathway
WikiPathways
Chromosomal and microsatellite instability in colorectal cancer
WikiPathways
Epithelial to mesenchymal transition in colorectal cancer
Name
Explore in Pharos
Explore in Source
Ciliary landscape
Ciliary landscape
Breast cancer pathway
Chromosomal and microsatellite instability in colorectal cancer
Epithelial to mesenchymal transition in colorectal cancer
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (90)
1 – 10 of 90
UQCC2
Tbio
Family: Enzyme
Novelty: 0.02059646
p_int: 0.999908502
p_ni: 0.000091498
Score: 0.964
Data Source: BioPlex,STRINGDB
COX20
Tbio
Family: Enzyme
Novelty: 0.04884442
p_int: 0.999244727
p_ni: 0.000755272
Score: 0.702
Data Source: BioPlex,STRINGDB
TM2D2
Tdark
Novelty: 0.10390283
p_int: 0.998189164
p_ni: 0.001810836
Score: 0.311
Data Source: BioPlex,STRINGDB
P3H1
Tbio
Family: Enzyme
Novelty: 0.02067711
p_int: 0.991771672
p_ni: 0.008228328
Score: 0.244
Data Source: BioPlex,STRINGDB
SRSF2
Tbio
Novelty: 0.00207072
p_int: 0.981950558
p_ni: 0.018049431
p_wrong: 1.1e-8
Data Source: BioPlex
CSNK1E
Tchem
Family: Kinase
Novelty: 0.00891859
p_int: 0.978834765
p_ni: 0.021165234
p_wrong: 1e-9
Data Source: BioPlex
CLMN
Tbio
Novelty: 0.0822701
p_int: 0.966911126
p_ni: 0.033088874
Data Source: BioPlex
FADS1
Tchem
Family: Enzyme
Novelty: 0.00160193
p_int: 0.948883929
p_ni: 0.051116071
Data Source: BioPlex
SYS1
Tbio
Novelty: 0.03311919
p_int: 0.932961408
p_ni: 0.06703859
p_wrong: 2e-9
Data Source: BioPlex
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.92852829
p_ni: 0.07147171
Data Source: BioPlex
Publication Statistics
PubMed Score  28.86

PubMed score by year
PubTator Score  14.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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