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Tbio
TMEM30A
Cell cycle control protein 50A

Protein Summary
Description
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230461
  • ENSP00000230461
  • ENSG00000112697
  • ENST00000370050
  • ENSP00000359067
  • ENST00000475111
  • ENSP00000431007

Symbol
  • C6orf67
  • CDC50A
  • CDC50A
  • C6orf67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.93
kinase perturbation
0.81
tissue sample
0.73
transcription factor binding site profile
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.76   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.76   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 30A
VGNC:3753
462827
Macaque
transmembrane protein 30A
717907
Mouse
MGI:106402
69981
Rat
RGD:1303315
300857
Dog
transmembrane protein 30A
VGNC:47570
474973
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 30A
Macaque
transmembrane protein 30A
Mouse
Rat
Dog
transmembrane protein 30A
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (205)
1 – 10 of 205
SARAF
Tbio
Novelty: 0.0383833
p_int: 0.999559633
p_ni: 0.000419961
p_wrong: 0.000020406
Score: 0.398
Data Source: BioPlex,STRINGDB
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.997540326
p_ni: 0.002459673
Score: 0.151
Data Source: BioPlex,STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.997389248
p_ni: 0.002585068
p_wrong: 0.000025685
Data Source: BioPlex
SMPD2
Tchem
Family: Enzyme
Novelty: 0.00375744
p_int: 0.995781917
p_ni: 0.004217748
p_wrong: 3.35e-7
Score: 0.155
Data Source: BioPlex,STRINGDB
CNNM1
Tdark
Novelty: 0.11053515
p_int: 0.994850383
p_ni: 0.004494219
p_wrong: 0.000655398
Score: 0.179
Data Source: BioPlex,STRINGDB
APP
Tchem
Novelty: 0.00008964
p_int: 0.991056418
p_ni: 0.008943582
Score: 0.153
Data Source: BioPlex,STRINGDB
DHRS7
Tbio
Family: Enzyme
Novelty: 0.16713756
p_int: 0.987877396
p_ni: 0.012122599
p_wrong: 5e-9
Score: 0.362
Data Source: BioPlex,STRINGDB
SEC11C
Tdark
Family: Enzyme
Novelty: 0.19577003
p_int: 0.98618598
p_ni: 0.01381402
Score: 0.535
Data Source: BioPlex,STRINGDB
HLA-C
Tbio
Novelty: 0.00698601
p_int: 0.98431327
p_ni: 0.01568673
Data Source: BioPlex
GRAMD1A
Tbio
Novelty: 0.15461113
p_int: 0.979319055
p_ni: 0.020680945
Data Source: BioPlex
Publication Statistics
PubMed Score  23.76

PubMed score by year
PubTator Score  10.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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