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Tbio
INTS9
Integrator complex subunit 9

Protein Summary
Description
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000416984
  • ENSP00000398208
  • ENSG00000104299
  • ENST00000521022
  • ENSP00000429065
  • ENST00000521777
  • ENSP00000430943

Symbol
  • RC74
  • INT9
  • RC74
  • CPSF2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
transcription factor binding site profile
0.92
histone modification site profile
0.78
phenotype
0.76
transcription factor
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.9   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.9   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
67.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
67.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 9
VGNC:859
745212
Macaque
integrator complex subunit 9
718598
Mouse
MGI:1098533
210925
Rat
RGD:1311539
290322
Dog
integrator complex subunit 9
VGNC:42058
486090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 9
Macaque
integrator complex subunit 9
Mouse
Rat
Dog
integrator complex subunit 9
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NV88-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (121)
1 – 10 of 121
NABP2
Tbio
Novelty: 0.09046897
p_int: 0.999998125
p_ni: 0.000001874
p_wrong: 1e-9
Score: 0.945
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.998276066
p_ni: 0.001361592
p_wrong: 0.000362342
Data Source: BioPlex
INTS6
Tbio
Novelty: 0.02680242
Score: 0.999
Data Source: STRINGDB
INTS3
Tbio
Novelty: 0.13398603
Score: 0.999
Data Source: STRINGDB
INTS5
Tbio
Novelty: 0.02127142
Score: 0.999
Data Source: STRINGDB
INTS4
Tdark
Novelty: 0.20868831
Score: 0.999
Data Source: STRINGDB
INTS1
Tbio
Novelty: 0.17523407
Score: 0.999
Data Source: STRINGDB
INTS11
Tbio
Novelty: 0.03333938
Score: 0.999
Data Source: STRINGDB
INTS12
Tbio
Family: Epigenetic
Novelty: 0.09023473
Score: 0.992
Data Source: STRINGDB
INTS10
Tbio
Novelty: 0.15415606
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.90

PubMed score by year
PubTator Score  2.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer