You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EXOC1
Exocyst complex component 1

Protein Summary
Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been descri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346134
  • ENSP00000326514
  • ENSG00000090989
  • ENST00000349598
  • ENSP00000334431
  • ENST00000381295
  • ENSP00000370695

Symbol
  • SEC3
  • SEC3L1
  • SEC3
  • SEC3P
  • BM-102
  • SEC3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
kinase perturbation
0.96
histone modification site profile
0.83
drug perturbation
0.71
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.05   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.05   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
EXOC3
Tbio
Novelty:  0.01051955
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOC6
Tbio
Novelty:  0.01886811
p_int:  0.999999993
p_ni:  7e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
NCKAP5L
Tdark
Novelty:  0.56142387
p_int:  0.999999887
p_ni:  1.6e-8
p_wrong:  9.7e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
TUFT1
Tbio
Novelty:  0.01999031
p_int:  0.999998786
p_ni:  0.000001214
Data Source:  BioPlex
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999997603
p_ni:  0.000002397
Data Source:  BioPlex
GRIPAP1
Tbio
Novelty:  0.09814766
p_int:  0.999996742
p_ni:  0.000003258
Data Source:  BioPlex
GOLGA4
Tbio
Novelty:  0.01363253
p_int:  0.999995934
p_ni:  0.000004065
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
p_int:  0.999995492
p_ni:  0.000004488
p_wrong:  2e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
EXOC2
Tbio
Novelty:  0.01434464
p_int:  0.999994695
p_ni:  0.000005305
Score:  0.999
Data Source:  BioPlex,STRINGDB
FKBP15
Tbio
Novelty:  0.0570695
p_int:  0.99999447
p_ni:  0.00000553
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Insulin processing
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Insulin processing
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
40.7
albuminuria
1
1
0
31.1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
40.7
albuminuria
0
31.1
7.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 1
VGNC:2037
471239
Macaque
exocyst complex component 1
695664
Mouse
MGI:2445020
69940
Dog
exocyst complex component 1
VGNC:51770
475149
Horse
exocyst complex component 1
VGNC:17718
100059087
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 1
Macaque
exocyst complex component 1
Mouse
Dog
exocyst complex component 1
Horse
exocyst complex component 1
Publication Statistics
PubMed Score 96.05
PubMed score by year
PubTator Score 48.42
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title