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Tbio
TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

Protein Classes
Protein Summary
Description
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359626
  • ENSP00000352645
  • ENSG00000198874
  • ENST00000361660
  • ENSP00000354795

Symbol
  • RSAFD1
  • TYW1A
  • RSAFD1
  • YPL207W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
protein domain
0.85
molecular function
0.81
disease perturbation
0.79
virus perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.17   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.17   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
40.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA-yW synthesizing protein 1 homolog B
472401
Macaque
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
703026
Mouse
MGI:2141161
100929
Rat
RGD:1310420
304423
Dog
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
479708
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA-yW synthesizing protein 1 homolog B
Macaque
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
Mouse
Rat
Dog
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NV66-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Synthesis of wybutosine at G37 of tRNA(Phe)
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Synthesis of wybutosine at G37 of tRNA(Phe)
tRNA modification in the nucleus and cytosol
tRNA processing
Protein-Protein Interactions (86)
1 – 10 of 86
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.998626183
p_ni:  0.001373817
Data Source:  BioPlex
BTN2A1
Tbio
Novelty:  0.02259329
p_int:  0.99642715
p_ni:  0.00357285
Data Source:  BioPlex
EVA1C
Tbio
Novelty:  0.45928677
p_int:  0.995496839
p_ni:  0.004503161
Data Source:  BioPlex
TSPAN17
Tdark
Novelty:  0.51639684
p_int:  0.994004117
p_ni:  0.005995883
Data Source:  BioPlex
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.993153389
p_ni:  0.006846611
Data Source:  BioPlex
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.991597388
p_ni:  0.008402612
Data Source:  BioPlex
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.991521179
p_ni:  0.008478821
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.988038224
p_ni:  0.011961776
Data Source:  BioPlex
DLK2
Tbio
Novelty:  0.06366405
p_int:  0.986335715
p_ni:  0.013664285
Data Source:  BioPlex
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.984542831
p_ni:  0.015457169
Data Source:  BioPlex
Publication Statistics
PubMed Score  23.17

PubMed score by year
PubTator Score  6.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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