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Tbio
MRGBP
MRG/MORF4L-binding protein

Protein Summary
Description
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370487
  • ENSP00000359518
  • ENSG00000101189

Symbol
  • C20orf20
  • Eaf7
  • URCC4
  • MRG15BP
  • C20orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.85
interacting protein
0.64
transcription factor perturbation
0.61
cellular component
0.6
tissue
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.44   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.44   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
64.9
BMI-adjusted waist circumference
1
1
1
59.8
C-reactive protein measurement
1
1
1
37.6
diastolic blood pressure
1
1
1
24.5
waist circumference
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
64.9
BMI-adjusted waist circumference
1
59.8
C-reactive protein measurement
1
37.6
diastolic blood pressure
1
24.5
waist circumference
1
17.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MRG domain binding protein
VGNC:6192
738462
Mouse
MGI:1920497
73247
Rat
RGD:1308612
311713
Horse
MRG domain binding protein
VGNC:20311
100058495
Cow
MRG domain binding protein
VGNC:31602
616297
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MRG domain binding protein
Mouse
Rat
Horse
MRG domain binding protein
Cow
MRG domain binding protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NV56-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (98)
1 – 10 of 98
MORF4L2
Tbio
Novelty:  0.09897629
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
EP400P1
Tdark
Novelty:  2.69614836
p_int:  1
Score:  0.923
Data Source:  BioPlex,STRINGDB
CEP250
Tbio
Novelty:  0.08014712
p_int:  0.999999892
p_ni:  1.08e-7
Data Source:  BioPlex
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999996293
p_ni:  0.000003707
Score:  0.997
Data Source:  BioPlex,STRINGDB
MBTD1
Tbio
Family:  Epigenetic
Novelty:  0.11651052
p_int:  0.999995426
p_ni:  0.000004574
Score:  0.878
Data Source:  BioPlex,STRINGDB
BRD8
Tbio
Family:  Epigenetic
Novelty:  0.09769287
p_int:  0.999993966
p_ni:  0.000006034
Score:  0.996
Data Source:  BioPlex,STRINGDB
EP400
Tbio
Novelty:  0.02013098
p_int:  0.99999262
p_ni:  0.00000738
Score:  0.995
Data Source:  BioPlex,STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
p_int:  0.999977209
p_ni:  0.000022791
Score:  0.994
Data Source:  BioPlex,STRINGDB
EPC1
Tbio
Novelty:  0.03216371
p_int:  0.999969667
p_ni:  0.000030333
Score:  0.995
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.44

PubMed score by year
PubTator Score  5.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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