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Tbio
NUDT15
Nucleotide triphosphate diphosphatase NUDT15

Protein Summary
Description
May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956). This gene encodes an enzyme that belongs to the Nudix hydrolase su ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258662
  • ENSP00000258662
  • ENSG00000136159

Symbol
  • MTH2
  • MTH2
  • NUDT15D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
tissue sample
0.76
transcription factor binding site profile
0.72
cell type or tissue
0.65
microRNA
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.66   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.66   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to thiopurine
4
1
0
8.1
98
3
1
0
5.8
98
1
1
0
35.6
97.7
3
1
0
5.8
93.6
Alopecia
1
1
0
10.4
72.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to thiopurine
0
8.1
98
0
5.8
98
0
35.6
97.7
0
5.8
93.6
Alopecia
0
10.4
72.2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NUDT proteins
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NUDT proteins
Purine catabolism
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (49)
1 – 10 of 49
LZTS2
Tbio
Novelty: 0.09515452
p_int: 0.998413147
p_ni: 0.000958245
p_wrong: 0.000628608
Score: 0.209
Data Source: BioPlex,STRINGDB
C1orf220
Tdark
p_int: 0.998163851
p_ni: 0.001598087
p_wrong: 0.000238062
Data Source: BioPlex
LCN15
Tdark
Novelty: 0.54935158
p_int: 0.805069689
p_ni: 0.01981423
p_wrong: 0.175116081
Score: 0.29
Data Source: BioPlex,STRINGDB
CLPSL1
Tdark
Family: Enzyme
Novelty: 0.32091586
p_int: 0.805069689
p_ni: 0.01981423
p_wrong: 0.175116081
Score: 0.269
Data Source: BioPlex,STRINGDB
NUDT5
Tbio
Family: Enzyme
Novelty: 0.02550535
Score: 0.84
Data Source: STRINGDB
NUDT18
Tbio
Family: Enzyme
Novelty: 0.24672611
Score: 0.826
Data Source: STRINGDB
TPMT
Tchem
Family: Enzyme
Novelty: 0.00272111
Score: 0.8
Data Source: STRINGDB
NUDT1
Tchem
Family: Enzyme
Novelty: 0.00383386
Score: 0.795
Data Source: STRINGDB
NUDT12
Tbio
Family: Enzyme
Novelty: 0.18740719
Score: 0.778
Data Source: STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00235169
Score: 0.717
Data Source: STRINGDB
Publication Statistics
PubMed Score  130.66

PubMed score by year
PubTator Score  49.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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