Tbio IMP3 U3 small nucleolar ribonucleoprotein protein IMP3

Protein Summary

Description

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NV31
• B3KQ67
• Q53G10
• U3 snoRNP protein IMP3

Gene Name

• IMP3

Ensembl ID

• ENST00000314852
• ENSP00000326981
• ENSG00000177971
• ENST00000403490
• ENSP00000385217

Symbol

• C15orf12
• MRPS4
• BRMS2
• MRPS4
• C15orf12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
virus perturbation	0.95
kinase perturbation	0.91
transcription factor binding site profile	0.79
interacting protein	0.78

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / U3 Small Nucleolar Ribonucleoprotein Protein Imp3

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / U3 Small Nucleolar Ribonucleoprotein Protein Imp3

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / U3 Small Nucleolar Ribonucleoprotein Protein Imp3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.58   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.58   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0