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Tbio
IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

Protein Summary
Description
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314852
  • ENSP00000326981
  • ENSG00000177971
  • ENST00000403490
  • ENSP00000385217

Symbol
  • C15orf12
  • MRPS4
  • BRMS2
  • MRPS4
  • C15orf12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
virus perturbation
0.95
kinase perturbation
0.91
transcription factor binding site profile
0.79
interacting protein
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.96   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.96   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (506)
MCC
Tbio
Novelty:  0.10374312
p_int:  0.999999984
p_ni:  1.7e-8
Data Source:  BioPlex
ATRX
Tbio
Novelty:  0.00114798
p_int:  0.999999852
p_ni:  1.47e-7
p_wrong:  1e-9
Data Source:  BioPlex
DIEXF
Tbio
Novelty:  0.05892659
p_int:  0.999999209
p_ni:  7.91e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
UTP3
Tbio
Novelty:  0.06371711
p_int:  0.999973723
p_ni:  0.000026277
Score:  0.999
Data Source:  BioPlex,STRINGDB
WDHD1
Tbio
Novelty:  0.01511313
p_int:  0.999946724
p_ni:  0.000053263
p_wrong:  1.3e-8
Data Source:  BioPlex
FMN2
Tbio
Novelty:  0.02031944
p_int:  0.999940389
p_ni:  0.00005961
Data Source:  BioPlex
TPM3
Tbio
Novelty:  0.00108151
p_int:  0.999935503
p_ni:  0.000064497
Score:  0.485
Data Source:  BioPlex,STRINGDB
MPHOSPH10
Tbio
Novelty:  0.04846226
p_int:  0.99984119
p_ni:  0.00015881
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
IMP4
Tdark
Novelty:  9.64444444
p_int:  0.999717952
p_ni:  0.000282015
p_wrong:  3.3e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
KIF18B
Tbio
Novelty:  0.06496349
p_int:  0.992334137
p_ni:  0.007665817
p_wrong:  4.6e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
4
4
73.1
glomerular filtration rate
1
4
4
70.9
serum urea measurement
1
2
2
49.5
body height
1
1
1
42.3
1
1
0
1.1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
4
73.1
glomerular filtration rate
4
70.9
serum urea measurement
2
49.5
body height
1
42.3
0
1.1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
IMP3, U3 small nucleolar ribonucleoprotein
706202
Mouse
MGI:1916119
102462
Rat
RGD:1306825
315697
Dog
IMP3, U3 small nucleolar ribonucleoprotein
VGNC:42006
487656
Cow
IMP3, U3 small nucleolar ribonucleoprotein
VGNC:30182
511560
Species
Name
OMA
EggNOG
Inparanoid
Macaque
IMP3, U3 small nucleolar ribonucleoprotein
Mouse
Rat
Dog
IMP3, U3 small nucleolar ribonucleoprotein
Cow
IMP3, U3 small nucleolar ribonucleoprotein
Publication Statistics
PubMed Score 2.96
PubMed score by year
PubTator Score 175.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title