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Tdark
TMEM140
Transmembrane protein 140

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275767
  • ENSP00000275767
  • ENSG00000146859
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.74
gene perturbation
0.68
transcription factor binding site profile
0.64
histone modification site profile
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
7.5
59.9
serum alanine aminotransferase measurement
2
1
1
6.3
52.7
monocyte percentage of leukocytes
1
1
1
48.5
monocyte count
1
1
1
40.7
alkaline phosphatase measurement
1
1
1
31.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
7.5
59.9
serum alanine aminotransferase measurement
1
6.3
52.7
monocyte percentage of leukocytes
1
48.5
monocyte count
1
40.7
alkaline phosphatase measurement
1
31.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915737
68487
Rat
RGD:1549759
362334
Dog
transmembrane protein 140
VGNC:47476
608116
Horse
transmembrane protein 140
VGNC:24201
100065089
Cow
transmembrane protein 140
VGNC:35973
515475
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane protein 140
Horse
transmembrane protein 140
Cow
transmembrane protein 140
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NV12-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (25)
1 – 10 of 25
STXBP1
Tbio
Novelty:  0.00339098
p_int:  0.902818733
p_ni:  0.041037483
p_wrong:  0.056143784
Data Source:  BioPlex
ITM2C
Tbio
Novelty:  0.10829732
Score:  0.62
Data Source:  STRINGDB
RFX3
Tbio
Family:  TF
Novelty:  0.04646733
Score:  0.597
Data Source:  STRINGDB
KHDC4
Tdark
Novelty:  0.47115316
Score:  0.588
Data Source:  STRINGDB
RTP4
Tbio
Novelty:  0.05959975
Score:  0.567
Data Source:  STRINGDB
ANKRD33B
Tdark
Novelty:  3.05956917
Score:  0.551
Data Source:  STRINGDB
TMEM40
Tdark
Novelty:  0.23945468
Score:  0.545
Data Source:  STRINGDB
PCDH12
Tbio
Novelty:  0.06268895
Score:  0.534
Data Source:  STRINGDB
SPG11
Tbio
Novelty:  0.00697875
Score:  0.533
Data Source:  STRINGDB
GAS2L3
Tbio
Novelty:  0.12695768
Score:  0.52
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.07

PubMed score by year
PubTator Score  2.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer