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Tbio
DCAF13
DDB1- and CUL4-associated factor 13

Protein Summary
Description
Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612750
  • ENSP00000484962
  • ENSG00000164934
  • ENST00000618975
  • ENSP00000480810

Symbol
  • WDSOF1
  • GM83
  • Sof1
  • WDSOF1
  • HSPC064
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.83
small molecule perturbation
0.8
transcription factor perturbation
0.8
histone modification site profile
0.75


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.74   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.74   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 13
VGNC:896
464328
Mouse
MGI:2684929
223499
Rat
RGD:1308458
362902
Dog
DDB1 and CUL4 associated factor 13
VGNC:39791
475065
Horse
DDB1 and CUL4 associated factor 13
VGNC:17028
100062586
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DDB1 and CUL4 associated factor 13
Mouse
Rat
Dog
DDB1 and CUL4 associated factor 13
Horse
DDB1 and CUL4 associated factor 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NV06-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
Metabolism of proteins
Neddylation
Post-translational protein modification
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (370)
1 – 10 of 370
WDR83
Tbio
Novelty: 0.11602568
p_int: 0.999999879
p_ni: 7.8e-8
p_wrong: 4.3e-8
Score: 0.529
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.999997282
p_ni: 0.000002707
p_wrong: 1.1e-8
Score: 0.289
Data Source: BioPlex,STRINGDB
CCT7
Tbio
Novelty: 0.02247038
p_int: 0.999958662
p_ni: 0.000041338
Score: 0.591
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.999546534
p_ni: 0.000453414
p_wrong: 5.2e-8
Score: 0.461
Data Source: BioPlex,STRINGDB
CCT5
Tbio
Novelty: 0.02369118
p_int: 0.998212944
p_ni: 0.001750527
p_wrong: 0.000036529
Score: 0.317
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.944178172
p_ni: 0.000485543
p_wrong: 0.055336285
Data Source: BioPlex
UTP6
Tbio
Novelty: 0.06525007
Score: 0.999
Data Source: STRINGDB
RRP9
Tbio
Novelty: 0.07232317
Score: 0.999
Data Source: STRINGDB
WDR36
Tbio
Novelty: 0.02010676
Score: 0.999
Data Source: STRINGDB
UTP15
Tbio
Novelty: 0.08174586
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.74

PubMed score by year
PubTator Score  6.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer