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Tbio
TBC1D23
TBC1 domain family member 23

Protein Summary
Description
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammator ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344949
  • ENSP00000340693
  • ENSG00000036054
  • ENST00000394144
  • ENSP00000377700

Symbol
  • NS4ATP1
  • PCH11
  • NS4ATP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
transcription factor binding site profile
0.77
kinase perturbation
0.76
transcription factor perturbation
0.74
tissue sample
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
2
2
55.8
BMI-adjusted waist circumference
1
1
1
21.5
refractive error measurement
1
1
1
21.5
facial morphology measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
2
55.8
BMI-adjusted waist circumference
1
21.5
refractive error measurement
1
21.5
facial morphology measurement
1
17.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 23
VGNC:7129
460554
Macaque
TBC1 domain family member 23
701253
Mouse
MGI:1914831
67581
Rat
RGD:1307925
304019
Dog
TBC1 domain family member 23
VGNC:47143
478539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 23
Macaque
TBC1 domain family member 23
Mouse
Rat
Dog
TBC1 domain family member 23
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NUY8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (72)
1 – 10 of 72
SLAMF7
Tclin
Novelty:  0.01014396
p_int:  0.999999992
p_ni:  8e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
FLYWCH2
Tdark
Novelty:  1.44186144
p_int:  0.999762863
p_ni:  0.000237127
p_wrong:  1e-8
Score:  0.638
Data Source:  BioPlex,STRINGDB
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999565375
p_ni:  0.000075108
p_wrong:  0.000359517
Data Source:  BioPlex
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.999439065
p_ni:  0.000250353
p_wrong:  0.000310582
Data Source:  BioPlex
TNFAIP6
Tbio
Novelty:  0.0046811
p_int:  0.999379184
p_ni:  0.00061877
p_wrong:  0.000002045
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.999214964
p_ni:  0.000785036
Data Source:  BioPlex
NPDC1
Tbio
Novelty:  0.05766647
p_int:  0.999208602
p_ni:  0.000782419
p_wrong:  0.000008979
Score:  0.214
Data Source:  BioPlex,STRINGDB
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.997834962
p_ni:  0.000195571
p_wrong:  0.001969466
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.978527411
p_ni:  0.000626081
p_wrong:  0.020846507
Data Source:  BioPlex
HS2ST1
Tbio
Family:  Enzyme
Novelty:  0.04520207
p_int:  0.975327765
p_ni:  0.00857479
p_wrong:  0.016097445
Score:  0.207
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.44

PubMed score by year
PubTator Score  4.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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