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Tbio
POT1
Protection of telomeres protein 1

Protein Summary
Description
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357628
  • ENSP00000350249
  • ENSG00000128513

Symbol
  • GLM9
  • CMM10
  • HPOT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
cellular component
0.76
disease perturbation
0.74
transcription factor binding site profile
0.74
biological term
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.17   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.17   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
67.1
1
1
0
1.2
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
67.1
0
1.2
31.2
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cell Cycle
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cell Cycle
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (29)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (99)
1 – 10 of 99
ACD
Tbio
Novelty: 0.00517732
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
TINF2
Tbio
Novelty: 0.0064505
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
TERF1
Tbio
Family: TF
Novelty: 0.00174529
p_int: 0.999999999
p_ni: 1e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
TERF2
Tbio
Family: TF
Novelty: 0.01003649
p_int: 0.999981015
p_ni: 0.00001898
p_wrong: 5e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
TERF2IP
Tchem
Novelty: 0.06285957
p_int: 0.996045709
p_ni: 0.003954291
Score: 0.995
Data Source: BioPlex,STRINGDB
DCLRE1B
Tbio
Family: Enzyme
Novelty: 0.0598925
Score: 0.987
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.974
Data Source: STRINGDB
STN1
Tbio
Novelty: 0.01309587
Score: 0.943
Data Source: STRINGDB
TERT
Tchem
Family: Enzyme
Novelty: 0.00024411
Score: 0.936
Data Source: STRINGDB
CTC1
Tbio
Novelty: 0.01298038
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  85.17

PubMed score by year
PubTator Score  169.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer