ABCB8
ATP-binding cassette sub-family B member 8, mitochondrial
Protein Summary
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
- ENST00000297504
- ENSP00000297504
- ENSG00000197150
- ENST00000358849
- ENSP00000351717
- ENST00000498578
- ENSP00000418271
- ENST00000542328
- ENSP00000438776
- MABC1
- MABC1
- M-ABC1
- EST328128
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
transcription factor binding site profile | 0.96 | ||
cellular component | 0.88 | ||
kinase perturbation | 0.76 | ||
histone modification site profile | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.86 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.86 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0