Protein Summary
- ENST00000401979
- ENSP00000384880
- ENSG00000153310
- ENST00000517654
- ENSP00000430674
- ENST00000519110
- ENSP00000429078
- ENST00000519540
- ENSP00000429499
- ENST00000519824
- ENSP00000429150
- ENST00000522250
- ENSP00000429978
- ENST00000522746
- ENSP00000428117
- ENST00000522941
- ENSP00000430433
- ENST00000523509
- ENSP00000429802
- L1
- BM-009
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.97 | ||
transcription factor binding site profile | 0.92 | ||
histone modification site profile | 0.89 | ||
kinase perturbation | 0.84 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.35 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 72 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.35 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 72 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (91)
FAM49A
Novelty: 0.40489408
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.489
Data Source: BioPlex,STRINGDB
GTF2E2
Novelty: 0.18033153
p_int: 0.999931176
p_ni: 0.000068781
p_wrong: 4.3e-8
Data Source: BioPlex
CDK19
Family: Kinase
Novelty: 0.03132669
p_int: 0.998025246
p_ni: 0.001974754
Data Source: BioPlex
FAM24B
Novelty: 1.04675689
p_int: 0.997570378
p_ni: 0.000176963
p_wrong: 0.002252659
Data Source: BioPlex
DNAAF2
Novelty: 0.01254416
p_int: 0.971611442
p_ni: 0.014891917
p_wrong: 0.01349664
Data Source: BioPlex
RAB3IL1
Novelty: 0.0167537
p_int: 0.867607856
p_ni: 0.132382691
p_wrong: 0.000009453
Score: 0.188
Data Source: BioPlex,STRINGDB
NUFIP1
Novelty: 0.11726869
p_int: 0.833473881
p_ni: 0.000624116
p_wrong: 0.165902003
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Reactome | Response to elevated platelet cytosolic Ca2+ | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hemostasis | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Response to elevated platelet cytosolic Ca2+ | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 85.3 | |||||
lymphocyte count | 2 | 2 | 2 | 84.7 | |||||
platelet count | 1 | 1 | 1 | 71 | |||||
BMI-adjusted hip circumference | 2 | 5 | 5 | 69.5 | |||||
red blood cell distribution width | 2 | 1 | 2 | 67.1 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 85.3 | |||||
lymphocyte count | 2 | 84.7 | |||||
platelet count | 1 | 71 | |||||
BMI-adjusted hip circumference | 5 | 69.5 | |||||
red blood cell distribution width | 2 | 67.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 49 member B | VGNC:3017 | 472859 | |||||
Macaque | family with sequence similarity 49 member B | 695449 | ||||||
Mouse | MGI:1923520 | 223601 | ||||||
Rat | RGD:1307697 | 299909 | ||||||
Dog | family with sequence similarity 49 member B | VGNC:40686 | 482041 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 49 member B | |||||
Macaque | family with sequence similarity 49 member B | |||||
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 49 member B | |||||
Publication Statistics
PubMed Score 36.35
PubMed score by year
PubTator Score 8.15
PubTator score by year
Related Publications
Text Mined References (20)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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