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Tbio
FAM49B
Protein FAM49B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401979
  • ENSP00000384880
  • ENSG00000153310
  • ENST00000517654
  • ENSP00000430674
  • ENST00000519110
  • ENSP00000429078
  • ENST00000519540
  • ENSP00000429499
  • ENST00000519824
  • ENSP00000429150
  • ENST00000522250
  • ENSP00000429978
  • ENST00000522746
  • ENSP00000428117
  • ENST00000522941
  • ENSP00000430433
  • ENST00000523509
  • ENSP00000429802

Symbol
  • L1
  • BM-009
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor binding site profile
0.92
histone modification site profile
0.89
kinase perturbation
0.84
transcription factor perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.35   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.35   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
FAM49A
Tdark
Novelty:  0.40489408
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.489
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.999931176
p_ni:  0.000068781
p_wrong:  4.3e-8
Data Source:  BioPlex
CDK19
Tchem
Family:  Kinase
Novelty:  0.03132669
p_int:  0.998025246
p_ni:  0.001974754
Data Source:  BioPlex
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.997570378
p_ni:  0.000176963
p_wrong:  0.002252659
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.971611442
p_ni:  0.014891917
p_wrong:  0.01349664
Data Source:  BioPlex
RAB3IL1
Tbio
Novelty:  0.0167537
p_int:  0.867607856
p_ni:  0.132382691
p_wrong:  0.000009453
Score:  0.188
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.833473881
p_ni:  0.000624116
p_wrong:  0.165902003
Data Source:  BioPlex
SERPINA1
Tbio
Novelty:  0.00014098
Score:  0.917
Data Source:  STRINGDB
ISLR
Tbio
Novelty:  0.02936208
Score:  0.905
Data Source:  STRINGDB
FERMT3
Tbio
Novelty:  0.01172918
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
85.3
lymphocyte count
2
2
2
84.7
platelet count
1
1
1
71
BMI-adjusted hip circumference
2
5
5
69.5
red blood cell distribution width
2
1
2
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
85.3
lymphocyte count
2
84.7
platelet count
1
71
BMI-adjusted hip circumference
5
69.5
red blood cell distribution width
2
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 49 member B
VGNC:3017
472859
Macaque
family with sequence similarity 49 member B
695449
Mouse
MGI:1923520
223601
Rat
RGD:1307697
299909
Dog
family with sequence similarity 49 member B
VGNC:40686
482041
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 49 member B
Macaque
family with sequence similarity 49 member B
Mouse
Rat
Dog
family with sequence similarity 49 member B
Publication Statistics
PubMed Score 36.35
PubMed score by year
PubTator Score 8.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title